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Article
Peer-Review Record

Polymorphisms within the SARS-CoV-2 Human Receptor Genes Associate with Variable Disease Outcomes across Ethnicities

Genes 2023, 14(9), 1798; https://doi.org/10.3390/genes14091798
by Theolan Adimulam 1, Thilona Arumugam 1, Anushka Naidoo 2, Kogieleum Naidoo 2,3 and Veron Ramsuran 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Genes 2023, 14(9), 1798; https://doi.org/10.3390/genes14091798
Submission received: 24 August 2023 / Revised: 7 September 2023 / Accepted: 13 September 2023 / Published: 14 September 2023
(This article belongs to the Special Issue Host Genetics and Infectious Disease)

Round 1

Reviewer 1 Report

The authors submitted an interesting article for review, however, before its publication it is required to be corrected:

- too briefly described methodology for testing genotypes, expressions or viral load, please specify the descriptions

- the description of the study group is incomprehensible, please correct this part

- in Table 1 - no number of patients in individual subgroups indicated in the Table

- Table 2 - the title of the Table is not fully understood

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

In the present manuscript, the authors studied the genetic variants within the SARS-CoV-2 receptors ACE2, TMPRSS2, CD147 and NRP1. They found there is a significant lower viral load of SARS-CoV-2 in Africans compared to Europeans and south Asians might because the specific SARS-CoV-2 receptor variants within different ethnics.

This manuscript is well written and the data support their conclusion.  

Author Response

Please see the attachment

Author Response File: Author Response.docx

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