PLEKHG1: New Potential Candidate Gene for Periventricular White Matter Abnormalities
Abstract
:1. Introduction
2. Materials and Methods
2.1. Library Preparation and Next-Generation Sequencing (NGS)
2.2. Data Analysis
3. Results
3.1. Clinical Report
3.2. Next Generation Sequencing (NGS)
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Tool | Significance | Score |
---|---|---|
MetaRNN | Pathogenic Strong | 0.9629 |
BayesDeladdAF | Pathogenic Moderate | 0.3782 |
BayesDelnoAF | Pathogenic Moderate | 0.3055 |
REVEL | Pathogenic Moderate | 0.906 |
MetaLR | Uncertain | 0.7318 |
MetaSVM | Uncertain | 0.7608 |
CADD | Pathogenic Supporting | 27.3 |
EIGEN | Pathogenic Moderate | 0.9774 |
EIGEN PC | Pathogenic Moderate | 0.8997 |
Mutation assessor | Pathogenic Moderate | 3.705 |
MutPred | Pathogenic Moderate | 0.855 |
FATHMM-MKL | Pathogenic Supporting | 0.9912 |
LIST-S2 | Pathogenic Supporting | 0.9889 |
LRT | Pathogenic Supporting | 0 |
MVP | Pathogenic Supporting | 0.9612 |
PolyPhen2 | Probably Damaging | 0.998 |
SIFT | Pathogenic Supporting | 0.001 |
DEOGEN2 | Benign Supporting | 0.3109 |
BLOSUM | Uncertain | −1 |
DANN | Damaging | 0.9981 |
FATHMM | Tolerated | −1.1 |
FATHMM-XF | Damaging | 0.8462 |
M-CAP | Damaging | 0.1503 |
MutationTaster | Disease causing | 0.9999 |
PrimateAI | Tolerated | 0.7779 |
PROVEAN | Damaging | −4.37 |
SIFT4G | Damaging | 0.007 |
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Calì, F.; Vinci, M.; Treccarichi, S.; Papa, C.; Gloria, A.; Musumeci, A.; Federico, C.; Vitello, G.A.; Nicotera, A.G.; Di Rosa, G.; et al. PLEKHG1: New Potential Candidate Gene for Periventricular White Matter Abnormalities. Genes 2024, 15, 1096. https://doi.org/10.3390/genes15081096
Calì F, Vinci M, Treccarichi S, Papa C, Gloria A, Musumeci A, Federico C, Vitello GA, Nicotera AG, Di Rosa G, et al. PLEKHG1: New Potential Candidate Gene for Periventricular White Matter Abnormalities. Genes. 2024; 15(8):1096. https://doi.org/10.3390/genes15081096
Chicago/Turabian StyleCalì, Francesco, Mirella Vinci, Simone Treccarichi, Carla Papa, Angelo Gloria, Antonino Musumeci, Concetta Federico, Girolamo Aurelio Vitello, Antonio Gennaro Nicotera, Gabriella Di Rosa, and et al. 2024. "PLEKHG1: New Potential Candidate Gene for Periventricular White Matter Abnormalities" Genes 15, no. 8: 1096. https://doi.org/10.3390/genes15081096