Multiscale Entropy of Resting-State Functional Magnetic Resonance Imaging Differentiates Progressive Supranuclear Palsy and Multiple System Atrophy
, Keiichi Onoda 2, Satoshi Abe 1, Chizuko Hamada 1, Shingo Mitaki 1, Hiroaki Oguro 1, Atsushi Nagai 1, Hajime Kitagaki 3 and Shuhei Yamaguchi 1Round 1
Reviewer 1 Report
I found this paper well written and the study was well designed and conducted. The results are very interesting. I only have one minor comment: p2 "Therefore, we introduced MSE to investigate" should be we applied MSE to investigate
Author Response
Dear, Reviewer
Please see the attachment.
Reviewer 2 Report
Thanks for recommending me as a reviewer. In this study, the authors aimed to examine whether rsfMRI data could differentiate between PSP and MSA via a multiscale entropy (MSE) analysis of BOLD signals, which estimates the complexity of temporal fluctuations in brain activity. If the authors complete the revision, the quality of the study will be further improved.
- The introduction section is well written. If the authors describe in more detail the theoretical background or research trend of Multiscale Entropy (MSE) analysis in the introduction section, it can help readers to understand.
2. page 3, "2.1. Patients" - Authors should be more specific about subject characteristics and sampling in the Study Methods section.
3. page 3, "2.2. Neuropsychological assessment " - If the authors describe the neuropsychological assessment used in this study more specifically (eg a cut-off point), it will be helpful for readers to understand.
4. "2.3 Image acquisition" and "2.4. Processing for functional imaging" are well written.
5. I suggest that the authors separate the last paragraph of the discussion section into a separate "conclusion section".
Author Response
Dear, Reviewer
Please see the attachment.
Author Response File: 
Author Response.docx
