Mean Platelet Volume as a Potential Marker of Large Vessel Occlusion and Predictor of Outcome in Acute Ischemic Stroke Patients Treated with Reperfusion Therapy
Abstract
:1. Background
2. Aim
3. Materials and Methods
Statistical Analysis
4. Results
4.1. Baseline Clinical Characteristics of Studied Cohort
4.2. Characteristics of Studied Subjects Stratified into MPV Quartiles
5. Discussion
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p * | Post Hoc ** | |
---|---|---|---|---|---|---|
n | 92 | 88 | 93 | 88 | ||
Age n (SD) | 68.3 (12.5) | 69 (13.9) | 71.7 (10.8) | 72.2 (12.4) | 0.1 | |
Sex (F) n (%) | 44 (23.8) | 52 (28.1) | 50 (27) | 39 (21) | 0.2 | |
AF | 22 (24) | 34 (38.6) | 39 (42) | 39 (44) | 0.01 | |
Hypertension | 62 (68) | 68 (77) | 75 (81) | 59 (68.6) | 0.1 | |
Diabetes | 12 (13) | 24 (27) | 26 (28) | 17 (20) | 0.06 | |
Smoking | 27 (30) | 14 (16) | 25 (27) | 14 (16) | 0.05 | |
Obesity | 124 (38) | 73 (23) | 54 (17) | 105 (33) | 0.2 | |
CHD | 24 (26) | 21 (24) | 23 (25) | 19 (22) | 0.9 | |
Dyslipidemia | 31 (34) | 23 (26) | 32 (34) | 20 (23) | 0.2 | |
Past stroke | 11 (12) | 14 (16) | 13 (14) | 12 (14) | 0.9 | |
OTG (MT) min | 257 (77) | 223 (62) | 246 (95) | 246 (73) | 0.6 | |
OTT (tPA) min | 168 (62) | 172 (62) | 178 (63) | 178 (65) | 0.9 | |
baseline RACE ≥ 5 | 24 (26) | 39 (44.3) | 56 (60.2) | 52 (59) | <0.01 | |
NIHSS baseline | 10.9 (5.2) | 13.2 (5.7) | 15 (6.2) | 14 (6.5) | <0.01 | 1 vs. 2,3,4 |
NIHSS 24 h | 7.4 (5.7) | 10.7 (7.6) | 12.5 (8.7) | 11.8 (8) | <0.01 | 1 vs. 3,4 |
NIHSS discharge | 3.9 (3.6) | 7 (5.8) | 8 (7.8) | 6.9 (7) | <0.01 | 1 vs. 2,3,4 |
mRSdischarge | 2.4 (1.8) | 3.5 (1.9) | 3.6 (1.8) | 3.5 (1.9) | <0.01 | 1 vs. 2,3,4 |
mRS ≤ 2 discharge | 57 (62) | 29 (33) | 27 (29) | 33 (37.5) | <0.01 | |
In-hospital mortality | 8 (8.7) | 14 (15.9) | 16 (17.2) | 13 (14.7) | 0.35 | |
Hyperdense MCA sign | 16 (18.3) | 25 (30.5) | 23 (28.8) | 28 (38.9) | 0.04 | 1 vs. 2,3,4 |
sICH hemorrhage | 10 (11) | 13 (15) | 21 (23) | 16 (18) | 0.17 | |
TICI 2b,3 (MT) | 11 (85) | 13(76) | 27 (69) | 44 (80) | 0.6 | |
ASPECTS score | 9.2 (0.5) | 9.1 (0.8) | 8.1 (1.2) | 8 (1.4) | 0.8 | |
LVO | 36 (39.1) | 38 (43.2) | 54 (58) | 66 (75) | <0.01 | |
Cardioembolic stroke | 24 (27) | 36 (40) | 41 (46) | 39 (43) | <0.05 | |
Atherothrombotic stroke | 33 (37) | 40 (44) | 42 (47) | 48 (53) | <0.05 |
Odds Ratio | −95%CI | +95%CI | p Value | |
---|---|---|---|---|
NIHSS baseline | 1.11 | 1.07 | 1.16 | <0.01 |
RACE baseline | 1.51 | 1.37 | 1.67 | <0.01 |
Age | 1.0 | 0.98 | 1.02 | 0.5 |
Age ≥ 65 | 1.11 | 0.89 | 1.39 | 0.3 |
MPV | 1.43 | 1.22 | 1.67 | <0.01 |
MPV quartile | 1.66 | 1.36 | 2.03 | <0.01 |
Hypertension | 1.0 | 0.62 | 1.61 | 0.9 |
AF | 1.33 | 0.86 | 2.05 | 0.2 |
Diabetes | 1.57 | 0.94 | 2.62 | 0.08 |
Smoking | 1.4 | 0.84 | 2.33 | 0.2 |
CHD | 2.21 | 1.33 | 3.69 | <0.01 |
Dyslipidemia | 1.19 | 0.75 | 1.88 | 0.4 |
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Dębiec, A.; Pogoda-Wesołowska, A.; Piasecki, P.; Stępień, A.; Staszewski, J. Mean Platelet Volume as a Potential Marker of Large Vessel Occlusion and Predictor of Outcome in Acute Ischemic Stroke Patients Treated with Reperfusion Therapy. Life 2021, 11, 469. https://doi.org/10.3390/life11060469
Dębiec A, Pogoda-Wesołowska A, Piasecki P, Stępień A, Staszewski J. Mean Platelet Volume as a Potential Marker of Large Vessel Occlusion and Predictor of Outcome in Acute Ischemic Stroke Patients Treated with Reperfusion Therapy. Life. 2021; 11(6):469. https://doi.org/10.3390/life11060469
Chicago/Turabian StyleDębiec, Aleksander, Aleksandra Pogoda-Wesołowska, Piotr Piasecki, Adam Stępień, and Jacek Staszewski. 2021. "Mean Platelet Volume as a Potential Marker of Large Vessel Occlusion and Predictor of Outcome in Acute Ischemic Stroke Patients Treated with Reperfusion Therapy" Life 11, no. 6: 469. https://doi.org/10.3390/life11060469