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Volume 11
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10.3390/life11060588
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Article

Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence

by
Anastasiya A. Kobelyatskaya
1,2,*,
Elena A. Pudova
1,
Anastasiya V. Snezhkina
1,
Maria S. Fedorova
1,
Vladislav S. Pavlov
1,
Zulfiya G. Guvatova
1,
Maria V. Savvateeva
1,
Nataliya V. Melnikova
1,
Alexey A. Dmitriev
1,
Dmitry Y. Trofimov
3,
Gennady T. Sukhikh
3,
Kirill M. Nyushko
4,
Boris Y. Alekseev
4,
Sergey V. Razin
2,
George S. Krasnov
1 and
Anna V. Kudryavtseva
1,*
1
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia
2
Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia
3
Gynecology and Perinatology named after Academician V.I. Kulakov, National Medical Research Center for Obstetrics, Ministry of Health of the Russian Federation, 117997 Moscow, Russia
4
National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Life 2021, 11(6), 588; https://doi.org/10.3390/life11060588
Submission received: 30 April 2021 / Revised: 7 June 2021 / Accepted: 16 June 2021 / Published: 21 June 2021
(This article belongs to the Section Physiology and Pathology)
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Abstract

Currently, seven molecular subtypes of prostate cancer (PCa) are known, the most common of which being the subtype characterized by the presence of the TMPRSS2–ERG fusion transcript. While there is a considerable amount of work devoted to the influence of this transcript on the prognosis of the disease, data on its role in the progression and prognosis of PCa remain controversial. The present study is devoted to the analysis of the association between the TMPRSS2–ERG transcript and the biochemical recurrence of PCa. The study included two cohorts: the RNA–Seq sample of Russian patients with PCa (n = 72) and the TCGA–PRAD data (n = 203). The results of the analysis of the association between the TMPRSS2–ERG transcript and biochemical recurrence were contradictory. The differential expression analysis (biochemical recurrence cases versus biochemical recurrence-free) and the gene set enrichment analysis revealed a list of genes involved in major cellular pathways. The GNL3, QSOX2, SSPO, and SYS1 genes were selected as predictors of the potential prognostic model (AUC = 1.000 for a cohort of Russian patients with PCa and AUC = 0.779 for a TCGA–PRAD cohort).
Keywords: prostate cancer; TMPRSS2–ERG molecular subtype; tumor recurrence; gene expression; RNA–Seq prostate cancer; TMPRSS2–ERG molecular subtype; tumor recurrence; gene expression; RNA–Seq

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MDPI and ACS Style

Kobelyatskaya, A.A.; Pudova, E.A.; Snezhkina, A.V.; Fedorova, M.S.; Pavlov, V.S.; Guvatova, Z.G.; Savvateeva, M.V.; Melnikova, N.V.; Dmitriev, A.A.; Trofimov, D.Y.; et al. Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence. Life 2021, 11, 588. https://doi.org/10.3390/life11060588

AMA Style

Kobelyatskaya AA, Pudova EA, Snezhkina AV, Fedorova MS, Pavlov VS, Guvatova ZG, Savvateeva MV, Melnikova NV, Dmitriev AA, Trofimov DY, et al. Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence. Life. 2021; 11(6):588. https://doi.org/10.3390/life11060588

Chicago/Turabian Style

Kobelyatskaya, Anastasiya A., Elena A. Pudova, Anastasiya V. Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Zulfiya G. Guvatova, Maria V. Savvateeva, Nataliya V. Melnikova, Alexey A. Dmitriev, Dmitry Y. Trofimov, and et al. 2021. "Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence" Life 11, no. 6: 588. https://doi.org/10.3390/life11060588

APA Style

Kobelyatskaya, A. A., Pudova, E. A., Snezhkina, A. V., Fedorova, M. S., Pavlov, V. S., Guvatova, Z. G., Savvateeva, M. V., Melnikova, N. V., Dmitriev, A. A., Trofimov, D. Y., Sukhikh, G. T., Nyushko, K. M., Alekseev, B. Y., Razin, S. V., Krasnov, G. S., & Kudryavtseva, A. V. (2021). Impact TMPRSS2–ERG Molecular Subtype on Prostate Cancer Recurrence. Life, 11(6), 588. https://doi.org/10.3390/life11060588

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