Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context?

Wazzani, Rkia; Pallu, Stéphane; Bourzac, Céline; Ahmaïdi, Saïd; Portier, Hugues; Jaffré, Christelle

doi:10.3390/life11080783

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Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context?

by

Rkia Wazzani

^1,†,

Stéphane Pallu

^2,3,†,

Céline Bourzac

²

,

Saïd Ahmaïdi

¹,

Hugues Portier

^2,3,†

and

Christelle Jaffré

^1,2,*,†

¹

Laboratoire APERE, Université de Picardie Jules Verne, CEDEX, F-80000 Amiens, France

²

Laboratoire B3OA, Université de Paris, CEDEX, F-75010 Paris, France

³

UFR Science & Technique, Université d’Orléans, CEDEX, F-45100 Orléans, France

^*

Author to whom correspondence should be addressed.

^†

These four authors contributed equally to the manuscript.

Life 2021, 11(8), 783; https://doi.org/10.3390/life11080783

Submission received: 17 March 2021 / Revised: 11 June 2021 / Accepted: 21 July 2021 / Published: 2 August 2021

(This article belongs to the Special Issue Impact of Physical Exercises on Bone Activities)

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Abstract

Physical activity is widely recognized as a biotherapy by WHO in the fight and prevention of bone diseases such as osteoporosis. It reduces the risk of disabling fractures associated with many comorbidities, and whose repair is a major public health and economic issue. Bone tissue is a dynamic supportive tissue that reshapes itself according to the mechanical stresses to which it is exposed. Physical exercise is recognized as a key factor for bone health. However, the effects of exercise on bone quality depend on exercise protocols, duration, intensity, and frequency. Today, the effects of different exercise modalities on capillary bone vascularization, bone blood flow, and bone angiogenesis remain poorly understood and unclear. As vascularization is an integral part of bone repair process, the analysis of the preventive and/or curative effects of physical exercise is currently very undeveloped. Angiogenesis–osteogenesis coupling may constitute a new way for understanding the role of physical activity, especially in fracturing or in the integration of bone biomaterials. Thus, this review aimed to clarify the link between physical activities, vascularization, and bone repair.

Keywords: physical activity; bone vascularization; angiogenesis; VEGF; bone repair

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MDPI and ACS Style

Wazzani, R.; Pallu, S.; Bourzac, C.; Ahmaïdi, S.; Portier, H.; Jaffré, C. Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context? Life 2021, 11, 783. https://doi.org/10.3390/life11080783

AMA Style

Wazzani R, Pallu S, Bourzac C, Ahmaïdi S, Portier H, Jaffré C. Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context? Life. 2021; 11(8):783. https://doi.org/10.3390/life11080783

Chicago/Turabian Style

Wazzani, Rkia, Stéphane Pallu, Céline Bourzac, Saïd Ahmaïdi, Hugues Portier, and Christelle Jaffré. 2021. "Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context?" Life 11, no. 8: 783. https://doi.org/10.3390/life11080783

APA Style

Wazzani, R., Pallu, S., Bourzac, C., Ahmaïdi, S., Portier, H., & Jaffré, C. (2021). Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context? Life, 11(8), 783. https://doi.org/10.3390/life11080783

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context?

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