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Article

Atranorin, a Secondary Metabolite of Lichens, Exhibited Anxiolytic/Antidepressant Activity in Wistar Rats

by
Nicol Urbanska
1,
Patrik Simko
1,
Andrea Leskanicova
1,
Martina Karasova
2,
Zuzana Jendzelovska
1,
Rastislav Jendzelovsky
1,
Dajana Rucova
1,
Mariana Kolesarova
1,
Michal Goga
1,
Martin Backor
1,3 and
Terezia Kiskova
1,*
1
Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Šafárik University in Košice, 04154 Košice, Slovakia
2
Small Animal Clinic, University of Veterinary Medicine and Pharmacy in Košice, 04180 Košice, Slovakia
3
Department of Biochemistry and Biotechnology, Institute of Biotechnology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, 94976 Nitra, Slovakia
*
Author to whom correspondence should be addressed.
Life 2022, 12(11), 1850; https://doi.org/10.3390/life12111850
Submission received: 6 October 2022 / Revised: 30 October 2022 / Accepted: 8 November 2022 / Published: 11 November 2022
(This article belongs to the Collection The Role of Bioactive Natural Compounds in the Treatment of Diseases)
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Abstract

Atranorin (ATR) is one of lichens’ many known secondary metabolites. Most current studies have investigated the various effects of ATR in vitro and only sporadically in vivo. The latest data indicate that ATR may have anxiolytic/antidepressive effects. This study aimed to analyze the potential of ATR in a depression-like state in male Wistar rats. Pregnant females were stressed by restricting their mobility in the final week of pregnancy three times a day for 45 min each, for three following days. After birth, progeny aged 60 days was stressed repeatedly. The male progeny was divided into three groups as follows: CTR group as a healthy control (n = 10), DEP group as a progeny of restricted mothers (n = 10), and ATR group as a progeny of restricted mothers, treated daily for one month with ATR (n = 10; 10 mg/kg of body weight, p.o.). Our results show that ATR acts as an antioxidant and markedly changes animal behavior. Concomitantly, hippocampal neurogenesis increases in the hilus and subgranular zone, together with the number of NeuN mature neurons in the hilus and CA1 regions. Our results indicate a potential antidepressant/anxiolytic effect of ATR. However, further studies in this area are needed.
Keywords: atranorin; depression; anxiety; Wistar rats; hippocampus; neurogenesis; stress; reactive oxygen species atranorin; depression; anxiety; Wistar rats; hippocampus; neurogenesis; stress; reactive oxygen species

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MDPI and ACS Style

Urbanska, N.; Simko, P.; Leskanicova, A.; Karasova, M.; Jendzelovska, Z.; Jendzelovsky, R.; Rucova, D.; Kolesarova, M.; Goga, M.; Backor, M.; et al. Atranorin, a Secondary Metabolite of Lichens, Exhibited Anxiolytic/Antidepressant Activity in Wistar Rats. Life 2022, 12, 1850. https://doi.org/10.3390/life12111850

AMA Style

Urbanska N, Simko P, Leskanicova A, Karasova M, Jendzelovska Z, Jendzelovsky R, Rucova D, Kolesarova M, Goga M, Backor M, et al. Atranorin, a Secondary Metabolite of Lichens, Exhibited Anxiolytic/Antidepressant Activity in Wistar Rats. Life. 2022; 12(11):1850. https://doi.org/10.3390/life12111850

Chicago/Turabian Style

Urbanska, Nicol, Patrik Simko, Andrea Leskanicova, Martina Karasova, Zuzana Jendzelovska, Rastislav Jendzelovsky, Dajana Rucova, Mariana Kolesarova, Michal Goga, Martin Backor, and et al. 2022. "Atranorin, a Secondary Metabolite of Lichens, Exhibited Anxiolytic/Antidepressant Activity in Wistar Rats" Life 12, no. 11: 1850. https://doi.org/10.3390/life12111850

APA Style

Urbanska, N., Simko, P., Leskanicova, A., Karasova, M., Jendzelovska, Z., Jendzelovsky, R., Rucova, D., Kolesarova, M., Goga, M., Backor, M., & Kiskova, T. (2022). Atranorin, a Secondary Metabolite of Lichens, Exhibited Anxiolytic/Antidepressant Activity in Wistar Rats. Life, 12(11), 1850. https://doi.org/10.3390/life12111850

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