Categorization of the Aqueous Deficient Dry Eye by a Cut-Off Criterion of TMH Measured with Tearscope
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sample
2.2. Study Design and Diagnostic Criteria
- ADDE type: participants presented a TMH-SL ≤ 0.20 mm and an LLP > Closed Meshwork. The participants who formed the ADDE group were also subclassified into Mild-moderate ADDE if the TMH-SL was ≥0.10 mm or Moderate-severe ADDE if the TMH-SL was ≤0.10 mm.
- EDE type: participants presented a THM-SL ≥ 0.20 mm and an LLP ≤ Closed Meshwork.
2.3. Evaluation Procedures
2.3.1. Symptomatology Assessment
2.3.2. Tear Film Osmolarity
2.3.3. Tear Meniscus Height
2.3.4. Lipid Layer Pattern Evaluation
2.3.5. Fluorescein Break-Up Time and Corneal Staining
2.3.6. Statistical Analysis
3. Results
3.1. Assessment of TMH-Tc Cut-Off Values to Differentiate between ADDE and EDE Participants
3.2. Assessment of TMH-Tc Cut-Off Values to Differentiate between Mild-Moderate and Moderate-Severe ADDE Participants
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Age (Years) * | OSDI (Score) ** | Osmolarity (mOsm/L) * | Corneal Staining (Oxford Scheme) ** | FBUT (s) * | TMH-SL (mm) * | LLP (Guillon Scheme) ** | TMH-Tc (mm) * | ||
---|---|---|---|---|---|---|---|---|---|
Total Sample (n = 200) | Mean/Median | 42.84 | 25.00 | 318.40 | 1.00 | 7.76 | 0.186 | Close Meshwork | 0.173 |
SD/IQR | 16.86 | 18.75–35.42 | 18.51 | 0.00–1.00 | 6.17 | 0.089 | Open Meshwork—Wave | 0.077 | |
Minimum | 18.00 | 12.50 | 275.00 | 0.00 | 1.45 | 0.060 | Open Meshwork | 0.040 | |
Maximum | 71.00 | 77.08 | 400.00 | 4.00 | 41.60 | 0.740 | Colour | 0.640 |
Age (Years) * | OSDI (Score) ** | Osmolarity (mOsm/L) * | Corneal Staining (Oxford Scheme) ** | FBUT (s) * | TMH-SL (mm) * | LLP (Guillon Scheme) ** | TMH-Tc (mm) * | ||
---|---|---|---|---|---|---|---|---|---|
ADDE (n = 69) | Mean/Median | 46.14 | 25.00 | 319.83 | 1.00 | 8.55 | 0.140 | Wave | 0.143 |
SD/IRQ | 14.95 | 18.75–39.58 | 16.51 | 0.00–1.50 | 6.17 | 0.037 | Wave-amorphous | 0.054 | |
Minimum | 18.00 | 12.50 | 291.00 | 0.00 | 1.45 | 0.060 | Wave | 0.04 | |
Maximum | 71.00 | 60.42 | 400.00 | 4.00 | 41.60 | 0.190 | Colour | 0.33 | |
EDE (n = 66) | Mean/Media | 42.86 | 22.57 | 312.50 | 1.00 | 7.39 | 0.270 | Closed Meshwork | 0.228 |
SD/IQR | 18.66 | 16.67–34.09 | 19.42 | 0.00–1.00 | 4.20 | 0.105 | Open Meshwork—Closed Meshwork | 0.092 | |
Minimum | 18.00 | 12.50 | 275.00 | 0.00 | 1.83 | 0.200 | Open Meshwork | 0.080 | |
Maximum | 71.00 | 77.08 | 400.00 | 4.00 | 22.75 | 0.740 | Closed Meshwork | 0.640 | |
p | 0.260 ‡ | 0.142 † | 0.090 ‡ | 0.300 † | 0.300 ‡ | <0.001 ‡ | <0.001 † | <0.001 ‡ |
Age (Years) * | OSDI (Score) ** | Osmolarity (mOsm/L) * | Corneal Staining (Oxford Scheme) ** | FBUT (s) * | TMH-SL (mm) * | LLP (Guillon Scheme) ** | TMH-Tc (mm) * | ||
---|---|---|---|---|---|---|---|---|---|
ADDE Mild-moderate | Mean/Median | 45.24 | 29.17 | 317.65 | 1.00 | 9.45 | 0.157 | Wave | 0.159 |
SD/IQR | 15.16 | 18.75–37.50 | 13.35 | 0.00–1.00 | 8.68 | 0.022 | Wave—amorphous | 0.050 | |
Minimum | 18.00 | 12.50 | 291.00 | 0.00 | 1.75 | 0.011 | Wave | 0.070 | |
(n = 64) | Maximum | 68.00 | 60.42 | 368.00 | 3.00 | 14.60 | 0.200 | Colour | 0.330 |
ADDE Moderate-severe (n = 15) | Mean/Median | 48.40 | 25.00 | 327.13 | 1.00 | 4.91 | 0.081 | Wave | 0.228 |
SD/IQR | 14.45 | 20.00–41.67 | 23.81 | 0.00–2.00 | 3.01 | 0.023 | Wave-Colour | 0.092 | |
Minimum | 20.00 | 12.50 | 303.00 | 0.00 | 1.45 | 0.060 | Wave | 0.080 | |
Maximum | 71.00 | 60.42 | 400.00 | 4.00 | 10.45 | 0.100 | Colour | 0.640 | |
p | 0.513 ‡ | 0.884 † | 0.052 ‡ | 0.056 † | 0.047 ‡ | <0.001 ‡ | 0.222 † | <0.001 ‡ |
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Sabucedo-Villamarin, B.; Pena-Verdeal, H.; Garcia-Queiruga, J.; Giraldez, M.J.; Garcia-Resua, C.; Yebra-Pimentel, E. Categorization of the Aqueous Deficient Dry Eye by a Cut-Off Criterion of TMH Measured with Tearscope. Life 2022, 12, 2007. https://doi.org/10.3390/life12122007
Sabucedo-Villamarin B, Pena-Verdeal H, Garcia-Queiruga J, Giraldez MJ, Garcia-Resua C, Yebra-Pimentel E. Categorization of the Aqueous Deficient Dry Eye by a Cut-Off Criterion of TMH Measured with Tearscope. Life. 2022; 12(12):2007. https://doi.org/10.3390/life12122007
Chicago/Turabian StyleSabucedo-Villamarin, Belen, Hugo Pena-Verdeal, Jacobo Garcia-Queiruga, Maria Jesus Giraldez, Carlos Garcia-Resua, and Eva Yebra-Pimentel. 2022. "Categorization of the Aqueous Deficient Dry Eye by a Cut-Off Criterion of TMH Measured with Tearscope" Life 12, no. 12: 2007. https://doi.org/10.3390/life12122007