Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge
Abstract
:1. Introduction
2. Patients, Materials, and Methods
2.1. Study Population and Data Collection
2.2. Study Groups and Outcomes
2.3. Materials
2.4. Statistical Analysis
3. Results
3.1. TSH Levels in the Acute Phase (the M0 Group)
3.2. TSH Levels at the Three-Month Post-Discharge Visit (the M3 Group)
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic | TSH Assay Data not Available at M0 (N = 257) | TSH Assay Data Available at M0 (N = 191) | p Value | |||
---|---|---|---|---|---|---|
Median (IQR) or n (%) | Missing Data | Median (IQR) or n (%) | Missing Data | |||
Demographic data | ||||||
Age (year) | 69 (56–82) | 0 | 78 (66–86) | 0 | <0.0001 | |
Men | 155 (60.3%) | 0 | 89 (46.6%) | 0 | 0.0041 | |
Body mass index (kg/m²) | 29.0 (24.1–32.9) | 62 | 26.5 (22.5–31.2) | 38 | 0.0054 | |
Smoking history | 77 | 64 | 0.593 | |||
Never | 112 (43.6%) | 84 (44.0%) | ||||
Former smoker | 59 (23.0%) | 35 (18.3%) | ||||
Current smoker | 9 (3.5%) | 8 (4.2%) | ||||
Coexisting conditions | ||||||
Obesity | 91 (35.4%) | 56 | 52 (27.2%) | 34 | 0.0225 | |
Diabetes | 66 (25.7%) | 0 | 61 (31.9%) | 0 | 0.168 | |
Arterial hypertension | 144 (56.0%) | 0 | 127 (66.5%) | 0 | 0.0314 | |
Hyperlipidemia | 81 (31.5%) | 1 | 72 (37.7%) | 0 | 0.191 | |
Cardiovascular diseases | 134 (42.4%) | 0 | 62 (45.5%) | 0 | 0.563 | |
Pulmonary Disease | 39 (15.2%) | 0 | 23 (12.0%) | 0.407 | ||
Chronic kidney disease | 37 (14.4%) | 0 | 31 (16.2%) | 0 | 0.597 | |
Cancer | 41 (15.9%) | 0 | 33 (17.3%) | 0 | 0.797 | |
Thyroid disease | 18 (7.0%) | 0 | 52 (27.2%) | 0 | <0.0001 | |
Main laboratory findings on admission | ||||||
Glycaemia (mmol/L) | 6.7 (5.8–7.9) | 27 | 6.5 (5.6–8.5) | 12 | 0.691 | |
GFR (MDRD mL/min/1.73 m²) | 81.5 (56–110) | 5 | 79 (55–99) | 0 | 0.507 | |
ALAT >40 U/L | 81 (31.5%) | 32 | 51 (26.7%) | 11 | 0.110 | |
ASAT > 40 U/L | 127 (49.4%) | 31 | 93 (48.7%) | 11 | 0.367 | |
GGT > ULN | 107 (41.6%) | 42 | 84 (44%) | 17 | 0.838 | |
WBC × 109 per L | 6.4 (5–9.1) | 6 | 6.5 (4.6–9.2) | 0 | 0.868 | |
Lymphocytes × 109 per L | 0.9 (0.6–1.2) | 6 | 0.8 (0.6–1.2) | 0 | 0.340 | |
CRP mg/L | 89.2 (42.0–152.1) | 7 | 82 (25.3–160.6) | 0 | 0.332 |
Patient N° | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | 51 | 81 | 69 | 71 | 70 | 80 | 64 | 89 | 67 | 88 | 56 | 29 | 92 | 45 | 72 | 59 | 65 |
Sex (M = Male, W = female) | M | M | W | W | M | W | M | W | M | W | M | M | W | W | M | W | M |
TSH (N: 0.4–4 mIU/L) | 0.33 | 0.28 | 0.13 | 0.28 | 0.37 | 0.3 | 0.16 | 0.27 | 0.04 | 0.16 | 0.11 | 0.14 | 0.02 | 0.28 | 7.3 | 4.3 | 15.0 |
fT4 (N: 11.5–22.7 pmol/L) | NA | NA | 15.9 | 16 | 16.9 | 17.2 | 8.5 | NA | NA | 17.9 | 11.6 | 10.7 | NA | 15.5 | 10.1 | NA | 9.4 |
fT3 (N: 3.5–6.5 pmol/L) | NA | NA | 4.6 | 3.8 | 2.94 | NA | 2.7 | NA | NA | 3.3 | 2.8 | 3.4 | 4.6 | 3.0 | 3.6 | NA | 4.1 |
Critical form of COVID-19 | No | No | No | Yes | No | No | Yes | No | Yes | No | Yes | Yes | No | Yes | Yes | Yes | Yes |
Patient N° | I | II | III | IV | V | VI | VII |
---|---|---|---|---|---|---|---|
Age (years) | 43 | 69 | 67 | 51 | 56 | 38 | 77 |
Sex (M = Male, W = female) | W | W | M | W | W | M | W |
TSH (mIU/L) | 0.31 | 0.36 | 0.27 | 4.5 | 5.8 | 7.5 | 10.4 |
fT4 (pmol/L) | 13.6 | 1.5 | 12.9 | 13.3 | 14.9 | 15.7 | 15.5 |
fT4 within normal limits | Yes | Low | Yes | Yes | Yes | Yes | Yes |
fT3 (pmol/L) | NA | NA | NA | NA | NA | NA | NA |
Interval between admission and TSH assay (days) | 147 | 99 | 167 | 84 | 144 | 95 | 129 |
TSH during hospitalization | NA | NA | NA | NA | NA | NA | NA |
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Al-Salameh, A.; Scherman, N.; Adda, I.; André, J.; Zerbib, Y.; Maizel, J.; Lalau, J.-D.; Brochot, E.; Andrejak, C.; Desailloud, R. Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge. Life 2022, 12, 2014. https://doi.org/10.3390/life12122014
Al-Salameh A, Scherman N, Adda I, André J, Zerbib Y, Maizel J, Lalau J-D, Brochot E, Andrejak C, Desailloud R. Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge. Life. 2022; 12(12):2014. https://doi.org/10.3390/life12122014
Chicago/Turabian StyleAl-Salameh, Abdallah, Noémie Scherman, Imane Adda, Juliette André, Yoann Zerbib, Julien Maizel, Jean-Daniel Lalau, Etienne Brochot, Claire Andrejak, and Rachel Desailloud. 2022. "Thyrotropin Levels in Patients with Coronavirus Disease 2019: Assessment during Hospitalization and in the Medium Term after Discharge" Life 12, no. 12: 2014. https://doi.org/10.3390/life12122014