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Article

Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia

by
Camille Quenon
1,
Thierry Hennebelle
1,
Jean-François Butaud
2,
Raimana Ho
3,
Jennifer Samaillie
1,
Christel Neut
4,
Tamatoa Lehartel
3,
Céline Rivière
1,
Ali Siah
1,
Natacha Bonneau
1,
Sevser Sahpaz
1,
Sébastien Anthérieu
5,
Nicolas Lebegue
6,
Phila Raharivelomanana
3 and
Vincent Roumy
1,*
1
UMRT 1158 BioEcoAgro, Métabolites spécialisés d’origine végétale, Université de Lille, JUNIA, Université de Liège, Université de Picardie Jules Verne, 59006 Lille, France
2
Consultant in Forestry and Polynesian Botany, BP 52832, 98716 Pirae, Tahiti, French Polynesia
3
EIO, UMR 241, Université de la Polynésie Française, BP 6570, 98702 Faa’a, Tahiti, French Polynesia
4
Inserm U1286, Laboratoire de Bactériologie, CHU Lille, Faculté des Sciences Pharmaceutiques et Biologiques, Université Lille Nord de France, 59006 Lille, France
5
UMR-S1172, Neuroscience & Cognition INSERM, Faculté des Sciences Pharmaceutiques et Biologiques, Université Lille Nord de France, CEDEX, 59006 Lille, France
6
ULR 4483-IMPECS-IMPact de l’Environnement Chimique sur la Santé humaine, CHU Lille, Institut Pasteur de Lille, Université de Lille, 59006 Lille, France
*
Author to whom correspondence should be addressed.
Life 2022, 12(5), 733; https://doi.org/10.3390/life12050733
Submission received: 26 April 2022 / Revised: 11 May 2022 / Accepted: 11 May 2022 / Published: 14 May 2022
(This article belongs to the Section Plant Science)
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Abstract

A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat “infectious” diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves of Syzygium malaccense were usually used in mixture with rhizomes of Curcuma longa to treat infectious diseases such as cystitis. The methanolic plant extracts were tested in vitro with an agar microdilution method on 33 bacteria strains and 1 yeast to obtain their Minimal Inhibitory Concentration (MIC), and cytotoxicity against HepG2 cells were evaluated. Antimicrobial synergistic effects of methanolic plant extracts from leaves of Syzygium malaccense and rhizomes from Curcuma longa were also evaluated. The bio-guided isolation of leaf extract from Syzygium malaccense led to the identification of seven alkyl-salicylic acids (anacardic acids or ginkgolic acids C15:0, C15:1, C17:0, C17:1, C17:2, C17:3 and C19:1) described for the first time in this species. All compounds were tested against Staphylococcus aureus (18.75 < MIC < 75.0 µg/mL), Streptococcus pyogenes (2.34 < MIC < 18.75 µg/mL) and Pseudomonas aeruginosa (MIC = 150 µg/mL), and their structure–activity relationships were discussed. The methanolic extract and salicylic derivatives from S. malaccense showed an interesting antimicrobial activity against Gram+ bacteria, without toxicity on hepG2 cells at 400 μg/mL. Moreover, these antibacterial compounds have already been studied for their anti-inflammatory activity, which supports the therapeutic interest of S. malaccense against infectious diseases.
Keywords: Society Islands; traditional medicine; phytochemical; antimicrobial; salicylic compounds; Syzygium malaccense Society Islands; traditional medicine; phytochemical; antimicrobial; salicylic compounds; Syzygium malaccense

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MDPI and ACS Style

Quenon, C.; Hennebelle, T.; Butaud, J.-F.; Ho, R.; Samaillie, J.; Neut, C.; Lehartel, T.; Rivière, C.; Siah, A.; Bonneau, N.; et al. Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia. Life 2022, 12, 733. https://doi.org/10.3390/life12050733

AMA Style

Quenon C, Hennebelle T, Butaud J-F, Ho R, Samaillie J, Neut C, Lehartel T, Rivière C, Siah A, Bonneau N, et al. Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia. Life. 2022; 12(5):733. https://doi.org/10.3390/life12050733

Chicago/Turabian Style

Quenon, Camille, Thierry Hennebelle, Jean-François Butaud, Raimana Ho, Jennifer Samaillie, Christel Neut, Tamatoa Lehartel, Céline Rivière, Ali Siah, Natacha Bonneau, and et al. 2022. "Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia" Life 12, no. 5: 733. https://doi.org/10.3390/life12050733

APA Style

Quenon, C., Hennebelle, T., Butaud, J.-F., Ho, R., Samaillie, J., Neut, C., Lehartel, T., Rivière, C., Siah, A., Bonneau, N., Sahpaz, S., Anthérieu, S., Lebegue, N., Raharivelomanana, P., & Roumy, V. (2022). Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia. Life, 12(5), 733. https://doi.org/10.3390/life12050733

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