Next Article in Journal
Review: The Key Factors to Melanomagenesis
Next Article in Special Issue
Association of Circulating Neutrophils with Relative Volume of Lipid-Rich Necrotic Core of Coronary Plaques in Stable Patients: A Substudy of SMARTool European Project
Previous Article in Journal
Primary and Metastatic Cutaneous Melanomas Discriminately Enrich Several Ligand-Receptor Interactions
Previous Article in Special Issue
Dynamic Arterial Elastance to Predict Mean Arterial Pressure Decrease after Reduction of Vasopressor in Septic Shock Patients
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 13
Issue 1
10.3390/life13010182
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions

by
Ecaterina Neculae
1,2,†,
Evelina Maria Gosav
3,4,†,
Emilia Valasciuc
3,4,†,
Nicoleta Dima
3,4,
Mariana Floria
3,4,* and
Daniela Maria Tanase
3,4
1
Department of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2
Institute of Gastroenterology and Hepatology, “Sf. Spiridon” County Clinical Emergency Hospital Iasi, 700111 Iasi, Romania
3
Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
4
Internal Medicine Clinic, “St. Spiridon” County Clinical Emergency Hospital Iasi, 700111 Iasi, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2023, 13(1), 182; https://doi.org/10.3390/life13010182
Submission received: 14 December 2022 / Revised: 31 December 2022 / Accepted: 6 January 2023 / Published: 8 January 2023
(This article belongs to the Special Issue Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment)
Browse Figure
Versions Notes

Abstract

Oral microbiota formation begins from birth, and everything from genetic components to the environment, alongside the host’s behavior (such as diet, smoking, oral hygiene, and even physical activity), contributes to oral microbiota structure. Even though recent studies have focused on the gut microbiota’s role in systemic diseases, the oral microbiome represents the second largest community of microorganisms, making it a new promising therapeutic target. Periodontitis and dental caries are considered the two main consequences of oral bacterial imbalance. Studies have shown that oral dysbiosis effects are not limited locally. Due to technological advancement, research identified oral bacterial species in heart valves. This evidence links oral dysbiosis with the development of valvular heart disease (VHD). This review focuses on describing the mechanism behind prolonged local inflammation and dysbiosis, that can induce bacteriemia by direct or immune-mediated mechanisms and finally VHD. Additionally, we highlight emerging therapies based on controlling oral dysbiosis, periodontal disease, and inflammation with immunological and systemic effects, that exert beneficial effects in VHD management.
Keywords: oral microbiota; dysbiosis; valvular heart disease; therapeutic strategies oral microbiota; dysbiosis; valvular heart disease; therapeutic strategies

Share and Cite

MDPI and ACS Style

Neculae, E.; Gosav, E.M.; Valasciuc, E.; Dima, N.; Floria, M.; Tanase, D.M. The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions. Life 2023, 13, 182. https://doi.org/10.3390/life13010182

AMA Style

Neculae E, Gosav EM, Valasciuc E, Dima N, Floria M, Tanase DM. The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions. Life. 2023; 13(1):182. https://doi.org/10.3390/life13010182

Chicago/Turabian Style

Neculae, Ecaterina, Evelina Maria Gosav, Emilia Valasciuc, Nicoleta Dima, Mariana Floria, and Daniela Maria Tanase. 2023. "The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions" Life 13, no. 1: 182. https://doi.org/10.3390/life13010182

APA Style

Neculae, E., Gosav, E. M., Valasciuc, E., Dima, N., Floria, M., & Tanase, D. M. (2023). The Oral Microbiota in Valvular Heart Disease: Current Knowledge and Future Directions. Life, 13(1), 182. https://doi.org/10.3390/life13010182

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop