Continuous Positive Airway Pressure Reduces Plasma Neurochemical Levels in Patients with OSA: A Pilot Study
, Huei-Tyng Huang 5,†, Hsin-Yi Hung 6,†, Shang-Yang Lin 2, Wen-Hua Hsu 1, Fang-Yu Lee 2, Yi-Chun Kuan 2,7,8,9,10, Yin-Tzu Lin 11, Chia-Rung Hsu 7, Marc Stettler 12, Chien-Ming Yang 13, Jieni Wang 14, Ping-Jung Duh 15, Kang-Yun Lee 3, Dean Wu 2,7,8,9,10, Hsin-Chien Lee 16, Jiunn-Horng Kang 4,17,18, Szu-Szu Lee 2, Hsiu-Jui Wong 2, Cheng-Yu Tsai 3,12,* and Arnab Majumdar 12,*add
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Round 1
Reviewer 1 Report
First, I would like to compliment the authors for this investigation work.
Abstract: I would recommend including numeric data on the changes in the neurochemical biomarker levels. I find it adequate to include only the conceptual explanation in the simple summary section. However, the abstract section must include the main results with numeric values.
Section 2.4. Patients were requested to use CPAP for 4 h - 5 days. Was the adherence and time of use registered?
Section 3.1. What happened with the 2 remaining patients? 32 people were included. However, only two groups of 10 and 20 are described.
Figure 2. It is a Litle bit confusing; please, explain better what represents a), b), c), and d). The content is similar to Table 3, so it could even be eliminated.
Author Response
We appreciate your valuable suggestions. We have carefully revised our manuscript per your feedback.
Author Response File: 
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Reviewer 2 Report
The manuscript is clear. The study is rigorous, original, with interesting conclusions.A larger sample is needed.
Author Response
We appreciate your valuable suggestions. We have carefully revised our manuscript per your feedback.
Author Response File: Author Response.docx
Reviewer 3 Report
Dear Author (s)
1. There are recent meta-analyses about this subject. What is novelty?
2. Why did you measure plasma level, not CSF?
3. Compared to other studies, you have lower cases. Why?
4. Some references in the introduction are very old. Please change them with ones newer.
5. You missed some recent meta-analyses and reviews for citations.
6. Please describe :Aβ42 × T-Tau or Aβ42 / T-Tau. What are they showing?
7. What is clicinal significance?
Author Response
We appreciate your valuable suggestions. We have carefully revised our manuscript per your feedback.
Author Response File: Author Response.docx
Round 2
Reviewer 3 Report
Dear Author(s)
The manuscript is acceptable.
