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Volume 13
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10.3390/life13030625
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Article

Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography

by
Cristina L. Saratxaga
1,2,*,
Aintzane Asumendi
3,4,
Jesús Gardeazabal
4,5,
Rosa M. Izu
4,6,
Ana Sanchez
4,6,
Goikoana Cancho-Galan
4,7,
Celia Morales
3,
Sergio Lage
3,4,
Maria D. Boyano
3,4,
Olga M. Conde
2,8,9 and
Estibaliz Garrote
1,3
1
TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, C/Geldo. Edificio 700, 48160 Derio, Spain
2
Photonics Engineering Group, University of Cantabria, 39005 Santander, Spain
3
Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), 48940 Leioa, Spain
4
Biocruces Bizkaia Health Research Institute, 48903 Barakaldo, Spain
5
Dermatology Department, Cruces University Hospital, 48903 Barakaldo, Spain
6
Dermatology Department, Basurto University Hospital, 48013 Bilbao, Spain
7
Pathology Department, Basurto University Hospital, 48013 Bilbao, Spain
8
Valdecilla Biomedical Research Institute (IDIVAL), 39011 Santander, Spain
9
CIBER-BBN, Biomedical Research Networking Center—Bioengineering, Biomaterials, and Nanomedicine, Avda. Monforte de Lemos 3–5, Pabellón 11, Planta 0, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Life 2023, 13(3), 625; https://doi.org/10.3390/life13030625
Submission received: 6 December 2022 / Revised: 19 February 2023 / Accepted: 20 February 2023 / Published: 23 February 2023
(This article belongs to the Special Issue Melanoma Next Generation)
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Abstract

Background: Melanoma incidence has continued to rise in the latest decades, and the forecast is not optimistic. Non-invasive diagnostic imaging techniques such as optical coherence tomography (OCT) are largely studied; however, there is still no agreement on its use for the diagnosis of melanoma. For dermatologists, the differentiation of non-invasive (junctional nevus, compound nevus, intradermal nevus, and melanoma in-situ) versus invasive (superficial spreading melanoma and nodular melanoma) lesions is the key issue in their daily routine. Methods: This work performs a comparative analysis of OCT images using haematoxylin–eosin (HE) and anatomopathological features identified by a pathologist. Then, optical and textural properties are extracted from OCT images with the aim to identify subtle features that could potentially maximize the usefulness of the imaging technique in the identification of the lesion’s potential invasiveness. Results: Preliminary features reveal differences discriminating melanoma in-situ from superficial spreading melanoma and also between melanoma and nevus subtypes that pose a promising baseline for further research. Conclusions: Answering the final goal of diagnosing non-invasive versus invasive lesions with OCT does not seem feasible in the short term, but the obtained results demonstrate a step forward to achieve this.
Keywords: skin cancer; melanoma; OCT; HE; optical biopsy; histopathology; optical properties; textural properties; CADx skin cancer; melanoma; OCT; HE; optical biopsy; histopathology; optical properties; textural properties; CADx
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MDPI and ACS Style

Saratxaga, C.L.; Asumendi, A.; Gardeazabal, J.; Izu, R.M.; Sanchez, A.; Cancho-Galan, G.; Morales, C.; Lage, S.; Boyano, M.D.; Conde, O.M.; et al. Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography. Life 2023, 13, 625. https://doi.org/10.3390/life13030625

AMA Style

Saratxaga CL, Asumendi A, Gardeazabal J, Izu RM, Sanchez A, Cancho-Galan G, Morales C, Lage S, Boyano MD, Conde OM, et al. Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography. Life. 2023; 13(3):625. https://doi.org/10.3390/life13030625

Chicago/Turabian Style

Saratxaga, Cristina L., Aintzane Asumendi, Jesús Gardeazabal, Rosa M. Izu, Ana Sanchez, Goikoana Cancho-Galan, Celia Morales, Sergio Lage, Maria D. Boyano, Olga M. Conde, and et al. 2023. "Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography" Life 13, no. 3: 625. https://doi.org/10.3390/life13030625

APA Style

Saratxaga, C. L., Asumendi, A., Gardeazabal, J., Izu, R. M., Sanchez, A., Cancho-Galan, G., Morales, C., Lage, S., Boyano, M. D., Conde, O. M., & Garrote, E. (2023). Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography. Life, 13(3), 625. https://doi.org/10.3390/life13030625

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