Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration
Abstract
:1. Introduction
2. Gut Microbiota (GM) and Brain Relationship
3. Autophagy and Neurodegeneration
4. Relation of Gut Microbiota (GM) and Autophagy in Neurodegeneration
5. Role of Gut Microbiota (GM) and Metabolites in NDD Pathogenesis
5.1. Parkinson’s Disease (PD)
5.2. Alzheimer’s Disease (AD)
5.3. Huntington’s Disease (HD)
5.4. Amyotrophic Lateral Sclerosis (ALS)
5.5. Multiple Sclerosis (MS)
6. Therapeutic Interventions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study Model | Study Type | Modulators | Mechanism | Reference | |
---|---|---|---|---|---|
Disease/GD | Autophagy | ||||
Parkinson’s disease | In vivo | MPTP (Neurotoxic model for PD) |
| [104] | |
Parkinson’s disease | In vitro (PC12 cell) | Rotenone (Neurotoxic model for PD) | Sodium butyrate |
| [105] |
Multiple sclerosis | In vivo (Experimental autoimmune encephalomyelitis) | MCC950 and Rapamycin |
| [110] | |
Alzheimer’s disease | In vivo (3× Tg mice) | Probiotics (SLAB51) |
| [117] | |
Alzheimer’s disease | In vivo (3× Tg mice) | Probiotics (SLAB51) |
| [116] | |
Ageing mice model/oxidative damage model on cell | In vivo/in vitro (PC12 cell) | Urolithin A |
| [115] | |
Parkinson’s disease | In vivo | Manganese-induced neurotoxicity resembles PD | Fecal microbiota transplant (FMT) |
| [111] |
Parkinson’s disease | In vitro (Enteroendocrine cells) | Sodium butyrate |
| [106] | |
Neurological disorder mice model | In vivo | Microbial metabolite NAMO |
| [107] | |
Alzheimer’s disease rodent model | In vivo | Aβ1-42-induced rats | Fructooligosaccharide |
| [118] |
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Mitra, S.; Munni, Y.A.; Dash, R.; Sadhu, T.; Barua, L.; Islam, M.A.; Chowdhury, D.; Bhattacharjee, D.; Mazumder, K.; Moon, I.S. Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration. Life 2023, 13, 957. https://doi.org/10.3390/life13040957
Mitra S, Munni YA, Dash R, Sadhu T, Barua L, Islam MA, Chowdhury D, Bhattacharjee D, Mazumder K, Moon IS. Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration. Life. 2023; 13(4):957. https://doi.org/10.3390/life13040957
Chicago/Turabian StyleMitra, Sarmistha, Yeasmin Akter Munni, Raju Dash, Toma Sadhu, Largess Barua, Md. Ariful Islam, Dipannita Chowdhury, Debpriya Bhattacharjee, Kishor Mazumder, and Il Soo Moon. 2023. "Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration" Life 13, no. 4: 957. https://doi.org/10.3390/life13040957