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Review

An Update on Mitral Valve Aging

1
Department of Adult and Children Cardiovascular Recovery, Emergency Institute for Cardio-Vascular Diseases and Transplantation, 540139 Targu Mures, Romania
2
Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania
3
Department of Surgery, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540139 Targu Mures, Romania
4
Romanian Academy of Medical Sciences, 030173 Bucharest, Romania
5
Department of Cardiovascular Surgery, Emergency University Hospital, 050098 Bucharest, Romania
6
Research Center for Oncopathology and Translational Medicine (CCOMT), George Emil Palade University of Medicine, Pharmacy, Science and Technology, 540139 Targu Mures, Romania
*
Author to whom correspondence should be addressed.
Life 2024, 14(8), 950; https://doi.org/10.3390/life14080950
Submission received: 17 June 2024 / Revised: 21 July 2024 / Accepted: 26 July 2024 / Published: 28 July 2024
(This article belongs to the Section Medical Research)

Abstract

The aging process can have notable effects on the mitral valve. During life, the mitral valve undergoes various changes that can impact its structure and function. The purpose of this review is to present a comprehensive overview of the literature published up to February 2024 in the Medline database regarding the impact of aging on the mitral valve. The studies were combined with the personal experience of the authors. Until 2024, out of the 12,189 publications that deal with the mitral valve in elderly individuals, 308 refer to mitral valve aging. After reviewing these data, we selected and analyzed the 73 most informative works regarding the age-related transformation of the mitral valve. Understanding the mechanisms driving the aging of the mitral valve is crucial for enhancing diagnostic and therapeutic strategies for reducing age-related valve dysfunction and the subsequent cardiovascular complications.
Keywords: heart; mitral valve; aging heart; mitral valve; aging

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MDPI and ACS Style

Opris, C.E.; Suciu, H.; Opris, C.I.; Gurzu, S. An Update on Mitral Valve Aging. Life 2024, 14, 950. https://doi.org/10.3390/life14080950

AMA Style

Opris CE, Suciu H, Opris CI, Gurzu S. An Update on Mitral Valve Aging. Life. 2024; 14(8):950. https://doi.org/10.3390/life14080950

Chicago/Turabian Style

Opris, Carmen Elena, Horatiu Suciu, Cosmin Ioan Opris, and Simona Gurzu. 2024. "An Update on Mitral Valve Aging" Life 14, no. 8: 950. https://doi.org/10.3390/life14080950

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