Impact of Nebulized BromAc® on Mucus Plug Clearance in a Mechanically Ventilated Ex Vivo Ovine Lung Model of Obstructive Respiratory Conditions
Abstract
:1. Introduction
2. Materials and Methods
2.1. Drugs
2.2. Preparation of Drugs (Bromelain, AC, and BromAc®)
2.3. Preparation of Mucus Simulant
2.4. Ventilator Settings and Measurements
2.5. Mucus Simulant Administration and Nebulization of Drugs in Ovine Lung
2.6. Viscosity Measurements
2.7. Statistical Analysis
3. Results
3.1. Effect of Bromelain, Ac, and BromAc on Ventilatory Resistance
3.2. Effect of Bromelain, Ac, and BromAc on Ventilatory Compliance, Tidal Volume, and Peak Pressure
3.3. Effect of Bromelain, Acetylcysteine, and BromAc®™ on Mucus Viscosity Using Rheology
3.4. Viscosity and Ventilatory Parameters and Relationship in the Treatment Group and Control
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Valle, N.; Eapen, M.S.; Pillai, K.; Morris, R.; Akhter, J.; Mekkawy, A.H.; Morris, D.L.; Valle, S.J. Impact of Nebulized BromAc® on Mucus Plug Clearance in a Mechanically Ventilated Ex Vivo Ovine Lung Model of Obstructive Respiratory Conditions. Life 2024, 14, 1111. https://doi.org/10.3390/life14091111
Valle N, Eapen MS, Pillai K, Morris R, Akhter J, Mekkawy AH, Morris DL, Valle SJ. Impact of Nebulized BromAc® on Mucus Plug Clearance in a Mechanically Ventilated Ex Vivo Ovine Lung Model of Obstructive Respiratory Conditions. Life. 2024; 14(9):1111. https://doi.org/10.3390/life14091111
Chicago/Turabian StyleValle, Nicole, Mathew Suji Eapen, Krishna Pillai, Richard Morris, Javed Akhter, Ahmed H. Mekkawy, David L. Morris, and Sarah J. Valle. 2024. "Impact of Nebulized BromAc® on Mucus Plug Clearance in a Mechanically Ventilated Ex Vivo Ovine Lung Model of Obstructive Respiratory Conditions" Life 14, no. 9: 1111. https://doi.org/10.3390/life14091111