MR Imaging of Hemosiderin Deposition in the Ankle Joints of Patients with Haemophilia: The Contribution of a Multi-Echo Gradient-Echo Sequence—Correlation with Osteochondral Changes and the Number and Chronicity of Joint Bleeds
Abstract
:1. Introduction
2. Methods
2.1. Patients
2.2. MRI Technique
2.3. Imaging Analysis and Interpretation
2.4. Statistics
3. Results
3.1. Detection of Joint Hemosiderin Deposition with mGRE Sequence: Inter-Reader Agreement
3.2. The Association of Joint Hemosiderin Deposition with Synovial Thickening, Effusion, and Osteochondral Changes (OCC)
3.3. Association of Joint Hemosiderin Deposition with the Number and Chronicity of Joint Bleeds and Clinical Score
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Method | Radiologist | Sensitivity | Specificity | PPV | NPV | ICC |
---|---|---|---|---|---|---|
Conventional | A 1 | 85.0% (64.0–94.8%) | 95.2% (77.3–99.2%) | 94.4% (74.2–99.0%) | 87.0% (67.9–95.5%) | 0.894 (0.802–0.943) |
B 2 | 80.0 (58.4–91.3%) | 76.2% (54.9–89.4%) | 76.2% (54.9–89.4%) | 80.0% (58.4–91.3%) | 0.724 (0.480–0.853) | |
C 3 | 50.0% (29.9–70.1%) | 81.0% (60.0–92.3%) | 71.4% (45.4–88.3%) | 63.0% (44.2–78.5%) | 0.481 (0.049–0.720) | |
T2* | A 1 | 90.0% (69.9–97.2%) | 100% (84.5–100%) | 100% (82.4–100%) | 91.3% (73.2–97.6%) | 0.950 (0.906–0.973) |
B 2 | 95.0% (76.4–99.1%) | 95.2% (77.3–99.2%) | 95.% (76.4–99.1%) | 95.2% (77.3–99.2%) | 0.950 (0.906–0.973) | |
C 3 | 95.0% (76.4–99.1%) | 100% (84.5–100%) | 100% (83.2–100%) | 95.5% (78.2–99.2%) | 0.976 (0.954–0.987) |
Pt, No | Age | Rt/Lt Ankle | JBs, n | Years from Last JB | Clinical Score | JHD, Grades | Synovial Thickening | Effusion | OC Changes |
---|---|---|---|---|---|---|---|---|---|
1 | 17 | Rt | 13 | 1 | 1 | 1 | + | + | + |
Lt | 1 | 7 | 2 | 0 | − | + | − | ||
2 | 9 | Lt | 4 | 1 | 1 | 1 | − | + | − |
3 | 13 | Rt | 0 | 0 | 0 | 0 | − | − | − |
Lt | 4 | 9 | 1 | 0 | + | + | − | ||
4 | 12 | Rt | 0 | 0 | 0 | 1 | + | + | − |
Lt | 1 | 9 | 0 | 0 | − | − | − | ||
5 | 12 | Rt | 2 | 0.5 | 0 | 0 | + | − | − |
Lt | 4 | 1 | 0 | 0 | + | − | − | ||
6 | 16 | Rt | 4 | 0 | 0 | 1 | − | − | − |
Lt | 2 | 2 | 0 | 1 | + | + | − | ||
7 | 16 | Rt | 0 | 0 | 0 | 0 | − | − | − |
Lt | 1 | 5 | 0 | 1 | − | − | − | ||
8 | 14 | Rt | 4 | 4 | 0 | 1 | + | + | − |
Lt | 0 | 0 | 0 | 0 | − | − | − | ||
9 | 16 | Rt | 2 | 7 | 1 | 1 | + | + | − |
Lt | 3 | 2 | 1 | 3 | + | + | + | ||
10 | 14 | Rt | 3 | 1 | 1 | 1 | + | − | − |
Lt | 1 | 4 | 0 | 2 | + | + | − | ||
11 | 15 | Rt | 7 | 6 | 3 | 2 | + | + | + |
Lt | 9 | 3 | 0 | 2 | + | − | + | ||
12 | 9 | Rt | 0 | 0 | 2 | 0 | + | − | + |
Lt | 1 | 2 | 2 | 1 | + | − | − | ||
13 | 16 | Rt | 2 | 8 | 0 | 2 | + | + | − |
Lt | 20 | 1 | 1 | 3 | + | + | + | ||
14 | 14 | Rt | 0 | 0 | 2 | 2 | + | + | − |
Lt | 2 | 1 | 2 | 2 | + | + | + | ||
15 | 17 | Rt | 0 | 0 | 0 | 0 | − | + | − |
Lt | 4 | 12 | 0 | 0 | − | + | − | ||
16 | 17 | Rt | 0 | 0 | 0 | 0 | − | − | − |
Lt | 2 | 6 | 0 | 0 | − | + | − | ||
17 | 17 | Rt | 8 | 0.5 | 0 | 3 | + | + | + |
Lt | 2 | 9 | 0 | 1 | − | − | − | ||
18 | 17 | Rt | 1 | 5 | 2 | 0 | − | + | − |
Lt | 2 | 1 | 2 | 1 | − | + | − | ||
19 | 17 | Rt | 10 | 0.5 | 1 | 3 | + | + | + |
Lt | 0 | 0 | 0 | 0 | − | − | − | ||
20 | 15 | Rt | 1 | 6 | 0 | 0 | − | − | − |
Lt | 1 | 0.5 | 0 | 0 | − | + | − | ||
21 | 16 | Rt | 2 | 5 | 0 | 0 | − | − | − |
Lt | 4 | 11 | 0 | 0 | + | − | − |
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Papakonstantinou, O.; Karavasilis, E.; Martzoukos, E.; Velonakis, G.; Kelekis, N.; Pergantou, H. MR Imaging of Hemosiderin Deposition in the Ankle Joints of Patients with Haemophilia: The Contribution of a Multi-Echo Gradient-Echo Sequence—Correlation with Osteochondral Changes and the Number and Chronicity of Joint Bleeds. Life 2024, 14, 1112. https://doi.org/10.3390/life14091112
Papakonstantinou O, Karavasilis E, Martzoukos E, Velonakis G, Kelekis N, Pergantou H. MR Imaging of Hemosiderin Deposition in the Ankle Joints of Patients with Haemophilia: The Contribution of a Multi-Echo Gradient-Echo Sequence—Correlation with Osteochondral Changes and the Number and Chronicity of Joint Bleeds. Life. 2024; 14(9):1112. https://doi.org/10.3390/life14091112
Chicago/Turabian StylePapakonstantinou, Olympia, Efstratios Karavasilis, Epaminondas Martzoukos, Georgios Velonakis, Nikolaos Kelekis, and Helen Pergantou. 2024. "MR Imaging of Hemosiderin Deposition in the Ankle Joints of Patients with Haemophilia: The Contribution of a Multi-Echo Gradient-Echo Sequence—Correlation with Osteochondral Changes and the Number and Chronicity of Joint Bleeds" Life 14, no. 9: 1112. https://doi.org/10.3390/life14091112