The Effects of Lilium lancifolium Thunb. on the Alleviation of Joint Pain: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Component Analysis Using High-Performance Liquid Chromatography
2.2. Ethics and Study Design
2.3. Subjects
2.4. Investigational Products
2.5. Measurements
2.5.1. KL Grade
2.5.2. Pain Visual Analog Scale
2.5.3. Korean Western Ontario and McMaster University Osteoarthritis Index
2.5.4. WHOQOL-BREF (WHO Quality of Life—BREF)
2.6. Compliance and Safety Evaluation
2.7. Statistical Analysis
3. Results
3.1. Components Included in HY-LL
3.2. The Characteristics of Study Subjects
3.3. Results of Symptom Questionnaire Related to Joints
3.4. Effect of HY-LL on Quality of Life According to WHOQOL-BREF
3.5. Effect of HY-LL on Hematological Factors
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Analysis Method | Compound | Retention Time (min) | Concentration (μg/g) a |
---|---|---|---|
Method A | Regaloside A | 12.765 | 341.43 ± 8.07 |
Method B | Caffeic acid | 20.843 | 26.34 ± 0.05 |
p-coumaric acid | 24.728 | 16.04 ± 0.14 | |
Ferulic acid | 26.323 | 27.23 ± 2.02 | |
Hesperetin | 39.551 | 24.19 ± 0.20 |
HY-LL (n = 39) | Placebo (n = 38) | p-Value | |
---|---|---|---|
Sex (M/F) | 5/34 | 5/33 | >0.99 |
Age (years) a | 58.33 ± 5.05 | 60.24 ± 6.61 | 0.161 |
Height (cm) | 160.00 ± 5.94 | 158.76 ± 7.64 | 0.431 |
Weight (kg) | 63.91 ± 9.11 | 60.39 ± 7.86 | 0.074 |
BMI (kg/m2) b | 24.99 ± 3.56 | 23.97 ± 2.80 | 0.165 |
SBP (mmHg) c | 119.54 ± 12.27 | 120.82 ± 10.77 | 0.629 |
DBP (mmHg) d | 73.36 ± 10.07 | 73.68 ± 9.11 | 0.882 |
Variable | HY-LL (n = 39) | Placebo (n = 38) | p-Value | ||||
---|---|---|---|---|---|---|---|
Baseline | 12 Week | Change Value | Baseline | 12 Week | Change Value | ||
WBC a | 5.84 ± 1.26 | 5.79 ± 1.33 | −0.05 ± 1.08 | 5.69 ± 1.18 | 5.73 ± 1.39 | 0.04 ± 1.23 | 0.710 |
RBC b | 4.49 ± 0.39 | 4.57 ± 0.40 | 0.07 ± 0.19 | 4.52 ± 0.31 | 4.55 ± 0.29 | 0.03 ± 0.15 | 0.231 |
Hemoglobin | 13.64 ± 1.05 | 13.80 ± 1.15 | 0.16 ± 0.55 | 13.87 ± 0.99 | 13.86 ± 0.97 | −0.01 ± 0.50 | 0.107 |
ALP c | 195.56 ± 59.84 | 198.08 ± 56.16 | 2.52 ± 34.47 | 201.64 ± 54.95 | 202.52 ± 49.60 | 0.88 ± 27.09 | 0.792 |
AST d | 25.64 ± 10.01 | 25.94 ± 8.23 | 0.30 ± 11.13 | 25.14 ± 6.39 | 25.96 ± 8.60 | 0.82 ± 6.16 | 0.773 |
ALT e | 24.78 ± 14.09 | 26.70 ± 16.84 | 1.92 ± 18.01 | 23.44 ± 10.16 | 24.28 ± 12.15 | 0.84 ± 11.19 | 0.720 |
Albumin | 4.28 ± 0.23 | 4.27 ± 0.28 | −0.01 ± 0.30 | 4.30 ± 0.22 | 4.25 ± 0.30 | −0.05 ± 0.27 | 0.531 |
BUN f | 14.39 ± 3.90 | 13.88 ± 2.70 | −0.51 ± 3.28 | 14.15 ± 3.37 | 14.09 ± 4.03 | −0.06 ± 4.22 | 0.553 |
Creatinine | 0.83 ± 0.13 | 0.81 ± 0.13 | −0.02 ± 0.10 | 0.85 ± 0.18 | 0.83 ± 0.18 | −0.02 ± 0.11 | 0.775 |
Glucose | 97.20 ± 10.11 | 97.26 ± 12.28 | 0.06 ± 9.59 | 97.12 ± 12.25 | 97.28 ± 12.19 | 0.16 ± 8.03 | 0.955 |
Urine pH | 5.91 ± 1.01 | 5.87 ± 1.01 | −0.04 ± 1.19 | 5.61 ± 0.74 | 6.11 ± 1.04 | 0.50 ± 1.14 | 0.023 * |
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Jeon, S.; Lee, H.; Lee, J.-H.; Lee, K.; Hong, D.; Park, S.-D.; Shim, J.-J.; Lee, J.-L.; Lee, J.; Joo, J.-C. The Effects of Lilium lancifolium Thunb. on the Alleviation of Joint Pain: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Life 2024, 14, 1136. https://doi.org/10.3390/life14091136
Jeon S, Lee H, Lee J-H, Lee K, Hong D, Park S-D, Shim J-J, Lee J-L, Lee J, Joo J-C. The Effects of Lilium lancifolium Thunb. on the Alleviation of Joint Pain: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Life. 2024; 14(9):1136. https://doi.org/10.3390/life14091136
Chicago/Turabian StyleJeon, Soomin, Hayera Lee, Jae-Ho Lee, Kippeum Lee, Dongki Hong, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee, Jaehwan Lee, and Jong-Cheon Joo. 2024. "The Effects of Lilium lancifolium Thunb. on the Alleviation of Joint Pain: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial" Life 14, no. 9: 1136. https://doi.org/10.3390/life14091136