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Volume 15
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10.3390/life15020195
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Integrin β2 Plays a Significant Role in Therapeutic Angiogenesis Through Hematopoietic Stem Cell Transplantation

by
Orie Saino
1,
Yuko Ogawa
1,
Kazuta Yasui
2,
Akihiro Fuchizaki
2,
Rie Akamatsu
1,
Yoriko Irie
2,
Mitsunobu Tanaka
3,
Takafumi Kimura
2 and
Akihiko Taguchi
1,*
1
Department of Regenerative Medicine Research, Foundation for Biomedical Research and Innovation at Kobe, 2-2, Minatojima-Minamimachi, Chou-Ku, Kobe 650-0047, Hyogo, Japan
2
Japanese Red Cross Kinki Block Blood Center, 7-5-17, Asagi Saito, Ibaraki 567-0085, Osaka, Japan
3
National Defense Medical College, Department of Preventive Medicine and Public Health, 3-2, Namiki, Tokorozawa 359-8513, Saitama, Japan
*
Author to whom correspondence should be addressed.
Life 2025, 15(2), 195; https://doi.org/10.3390/life15020195
Submission received: 27 November 2024 / Revised: 23 January 2025 / Accepted: 26 January 2025 / Published: 28 January 2025
(This article belongs to the Special Issue Revolutionizing Neuroregeneration)
Versions Notes

Abstract

The efficacy of hematopoietic stem cell (HSC) therapy for cerebral infarction has been previously demonstrated. However, the lack of response in some patients has hindered its widespread use. To establish HSC therapy as a standard treatment, it is important to examine the causes of non-responsiveness. In this study, we aimed to identify the specifications of transplanted cells based on their therapeutic mechanisms to predict treatment success. We found that HSC therapy activates injured cerebral endothelial cells via gap junctions because cell adhesion between HSCs and the endothelium plays an essential role in cellular communication via gap junctions. The expression of the adhesion molecule integrin β2 (CD18) in CD34-positive (CD34+) cells was identified as critical for the therapeutic effect on cerebral infarction in a murine model. Cells with low CD18 expression exhibited a weaker therapeutic effect than cells with high CD18 expression, even when the same number of HSCs was administered. The expression of CD18 in CD34+ cells can be used as a specification marker for transplanted HSCs and is useful for identifying non-responders. Furthermore, quantification of CD18 expression is crucial for evaluating the cellular potential of cell-based therapies for diseases where therapeutic effects are mediated through cell adhesion.
Keywords: hematopoietic stem cell; cell therapy; adhesion factors; integrin β2; CD18; stroke hematopoietic stem cell; cell therapy; adhesion factors; integrin β2; CD18; stroke

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MDPI and ACS Style

Saino, O.; Ogawa, Y.; Yasui, K.; Fuchizaki, A.; Akamatsu, R.; Irie, Y.; Tanaka, M.; Kimura, T.; Taguchi, A. Integrin β2 Plays a Significant Role in Therapeutic Angiogenesis Through Hematopoietic Stem Cell Transplantation. Life 2025, 15, 195. https://doi.org/10.3390/life15020195

AMA Style

Saino O, Ogawa Y, Yasui K, Fuchizaki A, Akamatsu R, Irie Y, Tanaka M, Kimura T, Taguchi A. Integrin β2 Plays a Significant Role in Therapeutic Angiogenesis Through Hematopoietic Stem Cell Transplantation. Life. 2025; 15(2):195. https://doi.org/10.3390/life15020195

Chicago/Turabian Style

Saino, Orie, Yuko Ogawa, Kazuta Yasui, Akihiro Fuchizaki, Rie Akamatsu, Yoriko Irie, Mitsunobu Tanaka, Takafumi Kimura, and Akihiko Taguchi. 2025. "Integrin β2 Plays a Significant Role in Therapeutic Angiogenesis Through Hematopoietic Stem Cell Transplantation" Life 15, no. 2: 195. https://doi.org/10.3390/life15020195

APA Style

Saino, O., Ogawa, Y., Yasui, K., Fuchizaki, A., Akamatsu, R., Irie, Y., Tanaka, M., Kimura, T., & Taguchi, A. (2025). Integrin β2 Plays a Significant Role in Therapeutic Angiogenesis Through Hematopoietic Stem Cell Transplantation. Life, 15(2), 195. https://doi.org/10.3390/life15020195

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