Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code through Origin of Life
Abstract
:1. Introduction
2. Steps of the Proposed RNA-Peptide World Scenario
Steps towards Translation
2.1. Assumptions for Primordial Earth Conditions
2.2. Step 1. Stability Selection of RNA Complexes
2.3. Step 2. Peptide Formation Due to Hybridization of Aminoacylated RNA Oligos
2.4. Step 3. the Amino Acid Content of HDPs
2.5. Step 4. Peptide-Dependent Stability
2.6. Step 5. “Proto-Translation”
2.7. Step 6. Replication
2.8. Step 7. the Evolution of Functions
2.9. Step 8. the Emergence of Standard Genetic Code (SGC)
3. Discussion
3.1. “RNA World” or “RNA-Peptide” World?
3.2. Formation of Standard Genetic Code
Author Contributions
Funding
Conflicts of Interest
References
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Kunnev, D.; Gospodinov, A. Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code through Origin of Life. Life 2018, 8, 44. https://doi.org/10.3390/life8040044
Kunnev D, Gospodinov A. Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code through Origin of Life. Life. 2018; 8(4):44. https://doi.org/10.3390/life8040044
Chicago/Turabian StyleKunnev, Dimiter, and Anastas Gospodinov. 2018. "Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code through Origin of Life" Life 8, no. 4: 44. https://doi.org/10.3390/life8040044