The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms
Abstract
:1. Introduction
2. Materials and Methods
2.1. The Journey to Discover the Urinary Microbiota of Healthy Individuals
2.2. Urinary Microbiota in Healthy Male Individuals
2.3. The Urinary Microbiota and LUTS in Male Individuals
2.4. The Urinary Microbiota and BPH in Male Individuals
2.5. The Role of the Inflammasome in LUTS/BPH
2.6. Prospectives of Urinary Microbiota
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Subject | Study Population | Main Bacterial Taxa | Sample Collection | Technique Used |
---|---|---|---|---|
Nelson et al. (2010) [22] | Men aged ≥ 18 y without STI (n = 9) | Corynebacterium, Lactobacillus, Streptococcus, Staphylococcus, Propionibacterium | First-void urine | 16S rRNA GS |
Nelson et al. (2012) [23] | Healthy adolescent men (aged 14–17 y) (n = 18) | Lactobacillus, Streptococcus, Sneathia, Mycoplasma, Ureaplasma | First-void urine | 16S rRNA GS |
Dong et al. (2011) [24] | Men without STI (n = 10) | Lactobacillus, Sneathia, Veillonella, Corynebacterium, Prevotella, Streptococcus, Ureaplasma, Mycoplasma, Anaerococcus, Atopobium, Aerococcus, Staphylococcus, Gemella, Enterococcus, Finegoldia | First-void urine | 16S rRNA GS |
Fouts et al. (2012) [25] | Healthy men aged 24–50 y (n = 11) | Lactobacillus, Corynebacterium, Staphylococcus | MSU | 16S rRNA GS |
Lewiset al. (2013) [26] | Healthy men (n = 6) | Forty-six genera identified | MSU | 16S rRNA GS |
Gottschicket al. (2017) [27] | Healthy men (n = 31) | Prevotella amnii, Sneathia amnii, Shigella sonnei, Enterococcus faecalis, Streptococcus agalacticie, Citrobacter murliniae | MSU | 16S rRNA GS |
Modenaet al. (2017) [28] | Healthy men (n = 10) | Streptococcus, Lactobacillus, Prevotella, Corynebacterium, Pseudomonas | MSU | 16S rRNA GS |
Frølund et al. (2018) [29] | Healthy men (n = 46) | Gardnerella, Lactobacillus, Sneathia, Finegoldia, Alphaproteobacteria, Prevotella, Enterococcus | First-void urine | 16S rRNA GS |
Subject | Sample Size (n) | Sample Type | Analysis Method | Relevant Microbiota | Primary Finding |
---|---|---|---|---|---|
Lewis et al. (2013) [26] | 6 | MSU | 16S rRNA gene sequencing | Firmicutes, Proteobacteria, Actinobacteria, Fusobacteria, Bacteroidetes |
|
Bajic et al. (2020) [30] | 49 | MSU, TUC | EQUC, 16S rRNA gene sequencing | Streptococcus, Veillonella, Gardnerella, Staphylococcus, Candida |
|
Yu et al. (2015) [46] | 21 BPH, 13 Pc | Voided urine, EPS/seminal fluid | 16S rRNA gene sequencing with PCR-DGGE analysis | Eubacterium, Defluviicoccus |
|
Holland et al. (2019) [47] | 30 men | Urine & fecalsamples | 16S rRNA gene sequencing | Lachnospiraceae, Bacteoidaceae, Erysipelotrichaceae, Ruminococcaeceae, Prevotellaceae, Clostridiales, Veillonellaceae, Enterococcaceae, Corynebacteriaceae, Incertae |
|
Jain et al. (2020) [48] | 36 men | Resected tissue | EQUC, 16S rRNA gene sequencing, immunohistological staining | Coagulase-positive Staphylococcus, E. coli, Micrococcus species, Proteobacteria, Actinobacteria, Firmicutes, Bacteroidetes |
|
Lee et al. (2021) [49] | 77 men with BPH, 30controls | MSU | 16S MetagenomicSequencing | Haemophilus, Staphylococcus, Dolosigranulum, Listeria, Phascolarctobacterium, Enhydrobacter, Bacillus, [Ruminococcus] torques, Faecalibacterium, Finegoldia |
|
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Yu, S.H.; Jung, S.I. The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms. Diagnostics 2022, 12, 1862. https://doi.org/10.3390/diagnostics12081862
Yu SH, Jung SI. The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms. Diagnostics. 2022; 12(8):1862. https://doi.org/10.3390/diagnostics12081862
Chicago/Turabian StyleYu, Seong Hyeon, and Seung Il Jung. 2022. "The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms" Diagnostics 12, no. 8: 1862. https://doi.org/10.3390/diagnostics12081862