Incidence and Time Point of Sepsis Detection as Related to Different Sepsis Definitions in Severely Burned Patients and Their Accompanying Time Course of Pro-Inflammatory Biomarkers
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Approval
2.2. Participants
2.3. Measurement of Serum Plasma Biomarker Concentration
2.4. Patient-Related Data
2.5. Definition of Nosocomial Infections
2.6. Definitions of Sepsis
- American Burns Association 2007 (Sepsis ABA 2007)
- Sepsis-3
- Zurich Burn Center
2.7. Statistical Analysis
3. Results
3.1. Baseline Characteristics as Related to Different Sepsis Definitions
3.2. Biomarker Time Course as Related to Different Sepsis Definitions
3.3. Biomarker Time Course as Related to The Event of Sepsis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Patents
References
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Total | No Infection | Sepsis-3 | Sepsis ABA 2007 | Sepsis Zurich Burn Center | p | ||
---|---|---|---|---|---|---|---|
Number of patients (n,%) | 90 | 31 (34.4%) | 46 (51.1%) | 33 (36.7%) | 24 (26.6%) | - | |
Gender (n,%) | female | 18 (20%) | 6 (33.3%) | 9 (50%) | 7 (38.9%) | 5 (27.8%) | - |
male | 72 (80%) | 25 (34.7%) | 37 (51.4%) | 26 (36.1%) | 19 (26.4%) | - | |
Age (years; mean ± SD) | 48.5 ± 18.8 | 50.4 ± 20.6 | 47.1 ± 18.2 | 50.2 ± 17.3 | 43.5 ± 18.2 | 0.38 | |
TBSA (%; median, IQR) | 32 (21) | 29.5 (21.6) | 35 (24.5) | 36 (26) | 39.5 (28.8) | 0.28 | |
BMI (kg/m2; median, IQR) | 26.3 (6.8) | 27.6 (7.2) | 24.8 (6.8) | 24.7 (7) | 24.7 (7) | 0.93 | |
Inhalation injury (n, %) | 25 (27.8%) | 7 (28 %) | 16 (64%) | 16 (64%) | 8 (32%) | - | |
Total length of stay (days, median, IQR) | 28 (38) | 18 (24) | 46 (61.2) | 51 (77) | 58 (55.5) | 0.70 | |
ICU length of stay (days, median, IQR) | 16 (30) | 6.5 (11.5) | 28 (40) | 40 (60) | 44 (42.5) | 0.81 | |
ABSI (median, IQR) | 7.5 (4) | 7 (6) | 8 (3) | 9 (4) | 9 (4) | 0.55 | |
Baux score (median, IQR) | 84 (37.5) | 83.5 (48) | 86.5 (32) | 90 (35) | 91.5 (28.5) | 0.66 | |
Mortality (n, %) | 14 (15.5%) | 10 (71.4%) | 4 (28.6%) | 4 (28.6%) | 3 (21.4%) | - |
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Niggemann, P.; Rittirsch, D.; Buehler, P.K.; Schweizer, R.; Giovanoli, P.; Reding, T.; Graf, R.; Plock, J.A.; Klein, H.J. Incidence and Time Point of Sepsis Detection as Related to Different Sepsis Definitions in Severely Burned Patients and Their Accompanying Time Course of Pro-Inflammatory Biomarkers. J. Pers. Med. 2021, 11, 701. https://doi.org/10.3390/jpm11080701
Niggemann P, Rittirsch D, Buehler PK, Schweizer R, Giovanoli P, Reding T, Graf R, Plock JA, Klein HJ. Incidence and Time Point of Sepsis Detection as Related to Different Sepsis Definitions in Severely Burned Patients and Their Accompanying Time Course of Pro-Inflammatory Biomarkers. Journal of Personalized Medicine. 2021; 11(8):701. https://doi.org/10.3390/jpm11080701
Chicago/Turabian StyleNiggemann, Pia, Daniel Rittirsch, Philipp Karl Buehler, Riccardo Schweizer, Pietro Giovanoli, Theresia Reding, Rolf Graf, Jan Alexander Plock, and Holger Jan Klein. 2021. "Incidence and Time Point of Sepsis Detection as Related to Different Sepsis Definitions in Severely Burned Patients and Their Accompanying Time Course of Pro-Inflammatory Biomarkers" Journal of Personalized Medicine 11, no. 8: 701. https://doi.org/10.3390/jpm11080701