Impact of Palonosetron on Cough Suppression in Females Undergoing Sevoflurane-Remifentanil Anesthesia for Laparoscopic Cholecystectomy: A Randomized Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Anesthesia
2.3. Definition and Study Protocol
2.4. Statistical Analysis
3. Results
3.1. Study Population
3.2. Baseline Characteristics
3.3. Optimal Ce of Remifentanil
3.4. Emergence and Recovery Data
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Kim, E.S.; Bishop, M.J. Cough during emergence from isoflurane anesthesia. Anesth. Analg. 1998, 87, 1170–1174. [Google Scholar] [CrossRef]
- Canning, B.J.; Chang, A.B.; Bolser, D.C.; Smith, J.A.; Mazzone, S.B.; McGarvey, L. Anatomy and neurophysiology of cough: CHEST Guideline and Expert Panel report. Chest 2014, 146, 1633–1648. [Google Scholar] [CrossRef] [Green Version]
- Rosato, L.; Avenia, N.; Bernante, P.; De Palma, M.; Gulino, G.; Nasi, P.G.; Pelizzo, M.R.; Pezzullo, L. Complications of thyroid surgery: Analysis of a multicentric study on 14,934 patients operated on in Italy over 5 years. World J. Surg. 2004, 28, 271–276. [Google Scholar] [CrossRef]
- Drummond, J.C.; Patel, P.M.; Lemkuil, B.P. Anesthesia for neurologic surgery. In Miller’s Anesthesia, 8th ed.; Miller, R.D., Eriksson, L.I., Fleisher, L.A., Wiener-Kronish, J.P., Cohen, N.H., Young, W.L., Eds.; Elsevier/Saunders: Philadelphia, PA, USA, 2015; pp. 2158–2199. [Google Scholar]
- Von Ungern-Sternberg, B.S.; Davies, K.; Hegarty, M.; Erb, T.O.; Habre, W. The effect of deep vs. awake extubation on respiratory complications in high-risk children undergoing adenotonsillectomy: A randomised controlled trial. Eur. J. Anaesthesiol. 2013, 30, 529–536. [Google Scholar] [CrossRef] [PubMed]
- Tung, A.; Fergusson, N.A.; Ng, N.; Hu, V.; Dormuth, C.; Griesdale, D.G.E. Pharmacological methods for reducing coughing on emergence from elective surgery after general anesthesia with endotracheal intubation: Protocol for a systematic review of common medications and network meta-analysis. Syst. Rev. 2019, 8, 32. [Google Scholar] [CrossRef] [PubMed]
- Safavi, M.; Honarmand, A.; Khazaei, M. The effects of propofol, ketamine and combination of them in prevention of coughing and laryngospasm in patients awakening from general anesthesia: A randomized, placebo-controlled, double blind clinical trial. Adv. Biomed. Res. 2016, 5, 64. [Google Scholar] [PubMed]
- Mandel, J.E. Considerations for the use of short-acting opioids in general anesthesia. J. Clin. Anesth. 2014, 26, S1–S7. [Google Scholar] [CrossRef]
- Tung, A.; Fergusson, N.A.; Ng, N.; Hu, V.; Dormuth, C.; Griesdale, D.E.G. Medications to reduce emergence coughing after general anaesthesia with tracheal intubation: A systematic review and network meta-analysis. Br. J. Anaesth. 2020, 124, 480–495. [Google Scholar] [CrossRef] [Green Version]
- Apfel, C.C.; Korttila, K.; Abdalla, M.; Kerger, H.; Turan, A.; Vedder, I.; Zernak, C.; Danner, K.; Jokela, R.; Pocock, S.J.; et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N. Engl. J. Med. 2004, 350, 2441–2451. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Stoltz, R.; Cyong, J.C.; Shah, A.; Parisi, S. Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjects. J. Clin. Pharmacol. 2004, 44, 520–531. [Google Scholar] [CrossRef] [PubMed]
- Reddy, G.S.; Manjusruthi, B.; Jyothsna, G. Postoperative Nausea and Vomiting Prophylaxis: A Comparative Study of Ramosetron and Palonosetron in Patients Undergoing Laparoscopic Cholecystectomy—A Prospective Randomized Trial. Anesth. Essays Res. 2019, 13, 68–72. [Google Scholar] [PubMed]
- Chou, Y.L.; Mori, N.; Canning, B.J. Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2018, 314, R489–R498. [Google Scholar] [CrossRef] [PubMed]
- Tao, R.; Auerbach, S.B. Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system. J. Pharmacol. Exp. Ther. 2002, 303, 549–556. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Driessen, A.K.; Farrell, M.J.; Mazzone, S.B.; McGovern, A.E. Multiple neural circuits mediating airway sensations: Recent advances in the neurobiology of the urge-to-cough. Respir. Physiol. Neurobiol. 2016, 226, 115–120. [Google Scholar] [CrossRef] [Green Version]
- Dicpinigaitis, P.V. Potential future therapies for the management of cough: ACCP evidence-based clinical practice guidelines. Chest 2006, 129, 284S–286S. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Barnes, P.J. The problem of cough and development of novel antitussives. Pulm. Pharmacol. Ther. 2007, 20, 416–422. [Google Scholar] [CrossRef]
- Martini, C.H.; Boon, M.; Bevers, R.F.; Aarts, L.P.; Dahan, A. Evaluation of surgical conditions during laparoscopic surgery in patients with moderate vs deep neuromuscular block. Br. J. Anaesth. 2014, 112, 498–505. [Google Scholar] [CrossRef] [Green Version]
- Pace, N.L.; Stylianou, M.P. Advances in and limitations of up-and-down methodology: A précis of clinical use, study design, and dose estimation in anesthesia research. Anesthesiology 2007, 107, 144–152. [Google Scholar] [CrossRef] [Green Version]
- Stylianou, M.; Flournoy, N. Dose finding using the biased coin up-and-down design and isotonic regression. Biometrics 2002, 58, 171–177. [Google Scholar] [CrossRef]
- Fregoneze, J.B.; Oliveira, E.F.; Ribeiro, V.F.; Ferreira, H.S.; De Castro, E.S.E. Multiple opioid receptors mediate the hypotensive response induced by central 5-HT(3) receptor stimulation. Neuropeptides 2011, 45, 219–227. [Google Scholar] [CrossRef] [Green Version]
- Song, B.; Chen, W.; Marvizón, J.C. Inhibition of opioid release in the rat spinal cord by serotonin 5-HT(1A) receptors. Brain Res. 2007, 1158, 57–62. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ren, J.; Ding, X.; Greer, J.J. 5-HT1A receptor agonist Befiradol reduces fentanyl-induced respiratory depression, analgesia, and sedation in rats. Anesthesiology 2015, 122, 424–434. [Google Scholar] [CrossRef] [Green Version]
- Chu, L.F.; Liang, D.Y.; Li, X.; Sahbaie, P.; D’Arcy, N.; Liao, G.; Peltz, G.; David Clark, J. From mouse to man: The 5-HT3 receptor modulates physical dependence on opioid narcotics. Pharm. Genom. 2009, 19, 193–205. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Walstab, J.; Rappold, G.; Niesler, B. 5-HT(3) receptors: Role in disease and target of drugs. Pharmacol. Ther. 2010, 128, 146–169. [Google Scholar] [CrossRef]
- Wittmann, M.; Schaaf, T.; Peters, I.; Wirz, S.; Urban, B.W.; Barann, M. The effects of fentanyl-like opioids and hydromorphone on human 5-HT3A receptors. Anesth. Analg. 2008, 107, 107–112. [Google Scholar] [CrossRef] [PubMed]
- Moe, A.A.K.; McGovern, A.E.; Mazzone, S.B. Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough. Int. J. Biochem. Cell Biol. 2021, 135, 105981. [Google Scholar] [CrossRef] [PubMed]
- Mazzone, S.B.; Undem, B.J. Vagal Afferent Innervation of the Airways in Health and Disease. Physiol. Rev. 2016, 96, 975–1024. [Google Scholar] [CrossRef] [Green Version]
- Stone, R.A.; Worsdell, Y.M.; Fuller, R.W.; Barnes, P.J. Effects of 5-hydroxytryptamine and 5-hydroxytryptophan infusion on the human cough reflex. J. Appl. Physiol. (1985) 1993, 74, 396–401. [Google Scholar] [CrossRef] [PubMed]
- Faerber, L.; Drechsler, S.; Ladenburger, S.; Gschaidmeier, H.; Fischer, W. The neuronal 5-HT3 receptor network after 20 years of research—evolving concepts in management of pain and inflammation. Eur. J. Pharmacol. 2007, 560, 1–8. [Google Scholar] [CrossRef]
- Suzuki, R.; Morcuende, S.; Webber, M.; Hunt, S.P.; Dickenson, A.H. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat. Neurosci. 2002, 5, 1319–1326. [Google Scholar] [CrossRef]
- Suzuki, R.; Rahman, W.; Hunt, S.P.; Dickenson, A.H. Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury. Brain Res. 2004, 1019, 68–76. [Google Scholar] [CrossRef]
- Kayser, V.; Elfassi, I.E.; Aubel, B.; Melfort, M.; Julius, D.; Gingrich, J.A.; Hamon, M.; Bourgoin, S. Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain 2007, 130, 235–248. [Google Scholar] [CrossRef]
- McCleane, G.J.; Suzuki, R.; Dickenson, A.H. Does a single intravenous injection of the 5HT3 receptor antagonist ondansetron have an analgesic effect in neuropathic pain? A double-blinded, placebo-controlled cross-over study. Anesth. Analg. 2003, 97, 1474–1478. [Google Scholar] [CrossRef]
- Ernberg, M.; Wieslander Fältmars, A.; Hajizadeh Kopayeh, M.; Arzt Wallén, S.; Cankalp, T.; Christidis, N. The Effect of Granisetron on Sensory Detection and Pain Thresholds in Facial Skin of Healthy Young Males. Front. Neurol. 2020, 11, 237. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cho, K.; Lee, S.H.; Lee, W.; Chu, B.K.; Kim, M.H.; Lim, S.H.; Lee, K.M. Effect of pretreatment with palonosetron on withdrawal movement associated with rocuronium injection. Korean J. Anesthesiol. 2014, 66, 23–27. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ryu, H.B.; Kim, S.J. Analgesic effects of palonosetron in the intravenous propofol injection. Korean J. Anesthesiol. 2014, 66, 99–104. [Google Scholar] [CrossRef] [Green Version]
- Lee, S.Y.; Jeong, Y.Y.; Lee, B.H.; Kim, J.E. Sex-related differences in effect-site concentration of remifentanil for preventing anesthetic emergence cough in elderly patients. Clin. Interv. Aging 2018, 13, 81–89. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kim, H.Y.; Moon, Y.R.; Seok, S.; Kim, B.; Kim, J.E.; Lee, S.Y. Comparison of sevoflurane and desflurane on effect-site concentration of remifentanil for preventing anesthetic emergence cough in elderly female patients undergoing laparoscopic cholecystectomy. Clin. Interv. Aging 2018, 13, 1769–1777. [Google Scholar] [CrossRef] [Green Version]
- Gan, T.J.; Belani, K.G.; Bergese, S.; Chung, F.; Diemunsch, P.; Habib, A.S.; Jin, Z.; Kovac, A.L.; Meyer, T.A.; Urman, R.D.; et al. Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting. Anesth. Analg. 2020, 131, 411–448. [Google Scholar] [CrossRef] [PubMed]
- Ebihara, S.; Ebihara, T.; Kohzuki, M. Effect of aging on cough and swallowing reflexes: Implications for preventing aspiration pneumonia. Lung 2012, 190, 29–33. [Google Scholar] [CrossRef]
- Minto, C.F.; Schnider, T.W.; Shafer, S.L. Pharmacokinetics and pharmacodynamics of remifentanil. II. Model application. Anesthesiology 1997, 86, 24–33. [Google Scholar] [CrossRef] [PubMed]
Control (n = 24) | Palonosetron (n = 21) | p-Value | |
---|---|---|---|
Age (years) | 48.0 ± 13.2 | 52.7 ± 12.2 | 0.222 |
Height (cm) | 159.3 ± 6.1 | 157.4 ± 5.4 | 0.282 |
Weight (kg) | 63.8 ± 10.2 | 59.1 ± 9.7 | 0.126 |
ASA classification 1/2/3 | 15/9/0 | 12/8/1 | 0.871 |
Intubation attempts once/twice | 24/0 | 21/0 | 0.489 |
Operation time (min) | 45 (35–50) | 40 (35–50) | 0.756 |
Anesthesia time (min) | 75 (65–80) | 75 (65–80) | 0.881 |
Control (n = 24) | Palonosetron (n = 21) | p-Value | |
---|---|---|---|
Dixon’s method | |||
EC50 of remifentanil Ce (ng/mL) | 1.33 ± 0.38 | 1.42 ± 0.75 | 0.813 |
Isotonic regression method | |||
EC50 of remifentanil Ce (ng/mL) | 1.17 (0.86–1.43) | 0.88 (0.78–1.23) | |
EC95 of remifentanil Ce (ng/mL) | 1.90 (1.45–1.96) | 2.43 (1.94–2.47) |
Control (n = 24) | Palonosetron (n = 21) | p-Value | |
---|---|---|---|
During emergence | |||
Extubation time (min) | 11.0 ± 3.2 | 11.1 ± 3.5 | 0.942 |
EtSevo at eye opening (%) | 0.25 ± 0.1 | 0.21 ± 0.09 | 0.155 |
Respiratory complications | 0.611 | ||
Bradypnea | 3 (13%) | 1 (5%) | |
Laryngospasm | 0 | 0 | |
Desaturation | 0 | 0 | |
In the post-anesthesia care unit | |||
Sedation score 1/2/3/4/5/6 | 2/21/0/1/0/0 | 0/17/4/0/0/0 | 0.028 |
Nausea 1/2/3/4 | 20/2/0/2 | 18/3/0/0 | 0.482 |
Vomiting | 1 (4%) | 0 | >0.999 |
Pain (0–10) | 4.7 ± 2.2 | 5.2 ± 1.6 | 0.367 |
atients receiving antiemetics | 2 (8%) | 0 | 0.491 |
Patients receiving analgesics | 13 (54%) | 16 (76%) | 0.124 |
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Gil, H.-Y.; Kim, H.-Y.; Lee, H.-S.; Kim, N.-Y.; Kim, J.-E. Impact of Palonosetron on Cough Suppression in Females Undergoing Sevoflurane-Remifentanil Anesthesia for Laparoscopic Cholecystectomy: A Randomized Trial. J. Pers. Med. 2021, 11, 887. https://doi.org/10.3390/jpm11090887
Gil H-Y, Kim H-Y, Lee H-S, Kim N-Y, Kim J-E. Impact of Palonosetron on Cough Suppression in Females Undergoing Sevoflurane-Remifentanil Anesthesia for Laparoscopic Cholecystectomy: A Randomized Trial. Journal of Personalized Medicine. 2021; 11(9):887. https://doi.org/10.3390/jpm11090887
Chicago/Turabian StyleGil, Ho-Young, Ha-Yeon Kim, Hye-Sun Lee, Na-Young Kim, and Ji-Eun Kim. 2021. "Impact of Palonosetron on Cough Suppression in Females Undergoing Sevoflurane-Remifentanil Anesthesia for Laparoscopic Cholecystectomy: A Randomized Trial" Journal of Personalized Medicine 11, no. 9: 887. https://doi.org/10.3390/jpm11090887