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Review

Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review

1
Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia
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Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia
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Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia
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Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia
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Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif 21974, Saudi Arabia
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Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia
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Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Safaa, Dammam 34222, Saudi Arabia
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Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia
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Herbal Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, Uttar Pradesh, India
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Department of Pharmacology, School of Medicine, Maldives National University, Male 20402, Maldives
11
Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(8), 1292; https://doi.org/10.3390/jpm12081292
Submission received: 23 May 2022 / Revised: 25 July 2022 / Accepted: 1 August 2022 / Published: 6 August 2022
(This article belongs to the Section Epidemiology)

Abstract

Mortality and morbidity from influenza and other respiratory viruses are significant causes of concern worldwide. Infections in the respiratory tract are often underappreciated because they tend to be mild and incapacitated. On the other hand, these infections are regarded as a common concern in clinical practice. Antibiotics are used to treat bacterial infections, albeit this is becoming more challenging since many of the more prevalent infection causes have acquired a wide range of antimicrobial resistance. Resistance to frontline treatment medications is constantly rising, necessitating the development of new antiviral agents. Probiotics are one of several medications explored to treat respiratory viral infection (RVI). As a result, certain probiotics effectively prevent gastrointestinal dysbiosis and decrease the likelihood of secondary infections. Various probiotic bacterias and their metabolites have shown immunomodulating and antiviral properties. Unfortunately, the mechanisms by which probiotics are effective in the fight against viral infections are sometimes unclear. This comprehensive review has addressed probiotic strains, dosage regimens, production procedures, delivery systems, and pre-clinical and clinical research. In particular, novel probiotics’ fight against RVIs is the impetus for this study. Finally, this review may explore the potential of probiotic bacterias and their metabolites to treat RVIs. It is expected that probiotic-based antiviral research would be benefitted from this review’s findings.
Keywords: probiotics; viral infections; respiratory viral infections; immunomodulatory effects; SARS-CoV-2; probiotics delivery probiotics; viral infections; respiratory viral infections; immunomodulatory effects; SARS-CoV-2; probiotics delivery
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MDPI and ACS Style

Wahab, S.; Almaghaslah, D.; Mahmood, S.E.; Ahmad, M.F.; Alsayegh, A.A.; Abu Haddash, Y.M.; Rahman, M.A.; Ahamd, I.; Ahmad, W.; Khalid, M.; et al. Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review. J. Pers. Med. 2022, 12, 1292. https://doi.org/10.3390/jpm12081292

AMA Style

Wahab S, Almaghaslah D, Mahmood SE, Ahmad MF, Alsayegh AA, Abu Haddash YM, Rahman MA, Ahamd I, Ahmad W, Khalid M, et al. Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review. Journal of Personalized Medicine. 2022; 12(8):1292. https://doi.org/10.3390/jpm12081292

Chicago/Turabian Style

Wahab, Shadma, Dalia Almaghaslah, Syed Esam Mahmood, Md Faruque Ahmad, Abdulrahman A. Alsayegh, Yahya M. Abu Haddash, Mohammad Akhlaquer Rahman, Irfan Ahamd, Wasim Ahmad, Mohammad Khalid, and et al. 2022. "Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review" Journal of Personalized Medicine 12, no. 8: 1292. https://doi.org/10.3390/jpm12081292

APA Style

Wahab, S., Almaghaslah, D., Mahmood, S. E., Ahmad, M. F., Alsayegh, A. A., Abu Haddash, Y. M., Rahman, M. A., Ahamd, I., Ahmad, W., Khalid, M., Usmani, S., Ahmad, M. P., & Hani, U. (2022). Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review. Journal of Personalized Medicine, 12(8), 1292. https://doi.org/10.3390/jpm12081292

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