Bioradiotherapy with Cetuximab May Reduce the Risk of Neck Node Relapse in Locoregionally Advanced Laryngeal Glottic Carcinoma: May HER1-Profile Be Useful in the Bioselection of Patients?
, Stefano Settimi 2, Dario Antonio Mele 2, Francesca Brigato 2, Domenico Scannone 3, Jacopo Galli 2, Vincenzo Valentini 4, Gaetano Paludetti 2, Libero Lauriola 3 and Franco Oreste Ranelletti 5Round 1
Reviewer 1 Report
This is a well written paper discussing in a comprehensive manner the effects of HER1 expression and cetuximab administration in a subset of head and neck cancer patients. Apart from minor faults (e.g. figure 2 is cut in half) the information given is well understood.
There is a lot of self-citation from the first author (11/57 ~ 20% of all citations). Although not inappropriate or extreme, it still is a matter of concern. I think a reduction of self-citations to 15% (8 or 9 out of 57) of the total to be more acceptable.
Author Response
Thanks for your revision. We addressed the minor faults and corrected the figure 2 as required. We performed a reduction of self-citations as indicated.
Reviewer 2 Report
Dear Editor,
Thanks for the invitation to review this interesting manuscript. Except for minor English edits and a minor error in the presentation of figures (for example, fig 2 is cropped in the draft I read), the manuscript is in good shape for publication.
Author Response
Thanks for your revision. We addressed the minor English edits and corrected the figure 2 as required.
