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Sports
Volume 8
Issue 6
10.3390/sports8060080
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Commentary

Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer

by
Gabriel H. Zieff
1,*,
Chad W. Wagoner
1,
Craig Paterson
2,
Patricia Pagan Lassalle
1 and
Jordan T. Lee
1
1
Exercise and Sport Science, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8700, USA
2
School of Sport and Exercise, University of Gloucestershire, Cheltenham GL2 9HW, UK
*
Author to whom correspondence should be addressed.
Sports 2020, 8(6), 80; https://doi.org/10.3390/sports8060080
Submission received: 2 May 2020 / Revised: 22 May 2020 / Accepted: 26 May 2020 / Published: 31 May 2020
(This article belongs to the Special Issue Biological Relationship Between Skeletal Muscle and Whole-Body Health)
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Abstract

Breast cancer survivors suffer from disproportionate cardiovascular disease risk compared to age-matched controls. Beyond direct cardiotoxic effects due to treatments such as chemotherapy and radiation, breast-cancer-related reductions in skeletal muscle mass, quality and oxidative capacity may further contribute to cardiovascular disease risk in this population by limiting the ability to engage in aerobic exercise—a known promoter of cardiovascular health. Indeed, 20–30% decreases in peak oxygen consumption are commonly observed in breast cancer survivors, which are indicative of exercise intolerance. Thus, breast-cancer-related skeletal muscle damage may reduce exercise-based opportunities for cardiovascular disease risk reduction. Resistance training is a potential strategy to improve skeletal muscle health in this population, which in turn may enhance the capacity to engage in aerobic exercise and reduce cardiovascular disease risk.
Keywords: skeletal muscle; breast cancer; aerobic exercise; resistance training skeletal muscle; breast cancer; aerobic exercise; resistance training

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MDPI and ACS Style

H. Zieff, G.; W. Wagoner, C.; Paterson, C.; Pagan Lassalle, P.; T. Lee, J. Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer. Sports 2020, 8, 80. https://doi.org/10.3390/sports8060080

AMA Style

H. Zieff G, W. Wagoner C, Paterson C, Pagan Lassalle P, T. Lee J. Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer. Sports. 2020; 8(6):80. https://doi.org/10.3390/sports8060080

Chicago/Turabian Style

H. Zieff, Gabriel, Chad W. Wagoner, Craig Paterson, Patricia Pagan Lassalle, and Jordan T. Lee. 2020. "Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer" Sports 8, no. 6: 80. https://doi.org/10.3390/sports8060080

APA Style

H. Zieff, G., W. Wagoner, C., Paterson, C., Pagan Lassalle, P., & T. Lee, J. (2020). Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer. Sports, 8(6), 80. https://doi.org/10.3390/sports8060080

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