Next Article in Journal
Pathogenesis of Two Western Mediterranean West Nile Virus Lineage 1 Isolates in Experimentally Infected Red-Legged Partridges (Alectoris rufa)
Next Article in Special Issue
Equine Coital Exanthema: New Insights on the Knowledge and Leading Perspectives for Treatment and Prevention
Previous Article in Journal
Diversity and Function of Appressoria
Previous Article in Special Issue
Equid herpesvirus-1 Distribution in Equine Lymphoid and Neural Tissues 70 Days Post Infection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 10
Issue 6
10.3390/pathogens10060747
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Investigation of an EHV-1 Outbreak in the United States Caused by a New H752 Genotype

by
Nicola Pusterla
1,*,
Samantha Barnum
1,
Julia Miller
2,
Sarah Varnell
2,
Barbara Dallap-Schaer
3,
Helen Aceto
3 and
Aliza Simeone
4
1
Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
2
Alliance Equine Health Care, Glenmoore, PA 19343, USA
3
Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348, USA
4
Pennsylvania Department of Agriculture, Bureau of Animal Health, Collegeville, PA 17110, USA
*
Author to whom correspondence should be addressed.
Pathogens 2021, 10(6), 747; https://doi.org/10.3390/pathogens10060747
Submission received: 31 May 2021 / Revised: 7 June 2021 / Accepted: 10 June 2021 / Published: 13 June 2021
(This article belongs to the Special Issue Equine Herpesviruses)
Browse Figures
Review Reports Versions Notes

Abstract

Here we report on an EHV-1 outbreak investigation caused by a novel genotype H752 (histidine in amino acid position 752 of the ORF 30 gene). The outbreak involved 31 performance horses. Horses were monitored over a period of 35 days for clinical signs, therapeutic outcome and qPCR results of EHV-1 in blood and nasal secretions. The morbidity of the EHV-1 outbreak was 84% with 26 clinically infected horses displaying fever and less frequently anorexia and distal limb edema. Four horses showed mild transient neurological deficits. Clinically diseased horses experienced high viral load of EHV-1 in blood and/or nasal secretions via qPCR, while subclinically infected horses had detectable EHV-1 mainly in nasal secretions. The majority of infected horses showed a rise in antibody titers to EHV-1 during the outbreak. All 31 horses were treated with valacyclovir, while clinically infected horses further received flunixin meglumine and sodium heparin. This investigation highlights various relevant aspects of an EHV-1 outbreak caused by a new H752 genotype: (i) importance of early detection of EHV-1 infection; (ii) diagnostic challenge to assess H752 genotype; (iii) apparent benefit of valacyclovir use in the early stage of the outbreak; and (iv) weekly testing of blood and nasal secretions by qPCR in order to monitor individual infection status and lift quarantine.
Keywords: EHV-1; new genotype; H752; outbreak; horses EHV-1; new genotype; H752; outbreak; horses

Share and Cite

MDPI and ACS Style

Pusterla, N.; Barnum, S.; Miller, J.; Varnell, S.; Dallap-Schaer, B.; Aceto, H.; Simeone, A. Investigation of an EHV-1 Outbreak in the United States Caused by a New H752 Genotype. Pathogens 2021, 10, 747. https://doi.org/10.3390/pathogens10060747

AMA Style

Pusterla N, Barnum S, Miller J, Varnell S, Dallap-Schaer B, Aceto H, Simeone A. Investigation of an EHV-1 Outbreak in the United States Caused by a New H752 Genotype. Pathogens. 2021; 10(6):747. https://doi.org/10.3390/pathogens10060747

Chicago/Turabian Style

Pusterla, Nicola, Samantha Barnum, Julia Miller, Sarah Varnell, Barbara Dallap-Schaer, Helen Aceto, and Aliza Simeone. 2021. "Investigation of an EHV-1 Outbreak in the United States Caused by a New H752 Genotype" Pathogens 10, no. 6: 747. https://doi.org/10.3390/pathogens10060747

APA Style

Pusterla, N., Barnum, S., Miller, J., Varnell, S., Dallap-Schaer, B., Aceto, H., & Simeone, A. (2021). Investigation of an EHV-1 Outbreak in the United States Caused by a New H752 Genotype. Pathogens, 10(6), 747. https://doi.org/10.3390/pathogens10060747

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop