Next Article in Journal
Growth of Gram-Negative Bacteria in Antiseptics, Disinfectants and Hand Hygiene Products in Two Tertiary Care Hospitals in West Africa—A Cross-Sectional Survey
Previous Article in Journal
High Prevalence of Rickettsia raoultii Found in Dermacentor Ticks Collected in Barnaul, Altai Krai, Western Siberia
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 12
Issue 7
10.3390/pathogens12070915
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters

by
Snjezana Zidovec-Lepej
1,*,
Margarita Batovic
2,
Marija Rozman
1,
Kristian Bodulić
3,
Laura Prtorić
4,
Ante Šokota
4,
Andrea Nikcevic
4,
Petra Simicic
1 and
Goran Tešović
5
1
Department of Immunological and Molecular Diagnostics, University Hospital for Infectious Diseases, 10 000 Zagreb, Croatia
2
Department of Medical and Laboratory Genetics, Children’s Hospital Zagreb, 10 000 Zagreb, Croatia
3
Research Department, University Hospital for Infectious Diseases, 10 000 Zagreb, Croatia
4
Pediatric Infectious Diseases Department, University Hospital for Infectious Diseases, 10 000 Zagreb, Croatia
5
Department of Infectious Diseases, University of Zagreb School of Medicine, 10 000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Pathogens 2023, 12(7), 915; https://doi.org/10.3390/pathogens12070915
Submission received: 9 June 2023 / Revised: 30 June 2023 / Accepted: 4 July 2023 / Published: 6 July 2023
(This article belongs to the Section Viral Pathogens)
Browse Figures
Review Reports Versions Notes

Abstract

The molecular diversity of Epstein–Barr virus (EBV) is exceptionally complex and based on the characterization of sequences coding for several viral genes. The aim of this study was to analyze the distribution of EBV types 1 and 2 and to characterize LMP1 variants in a cohort of 73 patients with infectious mononucleosis (IM), as well as to investigate a possible association between viral diversity and relevant clinical parameters. Population-based sequencing of EBNA-2 gene showed the presence of EBV type 1 in all IM patients. Analysis of LMP1 gene found a restricted repertoire of LMP1 variants with the predominance of wild-type B95-8, China1, Mediterranean and North Carolina variants with the presence of more than one LMP1 variant in 16.4% of patients. Co-infections with different LMP1 variants were associated with significantly higher levels of C-reactive protein and lower levels of maximal neutrophil counts and minimal platelet count. The results of this study have shown a narrow repertoire of LMP1 variants and an exclusive presence of EBV type 1 in a cohort of IM from Croatia, suggesting a characteristic local molecular pattern of this virus. The clinical importance of distinct immunobiological features of IM patients with LMP1 variant co-infections needs to be investigated further.
Keywords: Epstein–Barr virus; LMP1; genotyping; co-infections; infectious mononucleosis Epstein–Barr virus; LMP1; genotyping; co-infections; infectious mononucleosis

Share and Cite

MDPI and ACS Style

Zidovec-Lepej, S.; Batovic, M.; Rozman, M.; Bodulić, K.; Prtorić, L.; Šokota, A.; Nikcevic, A.; Simicic, P.; Tešović, G. Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters. Pathogens 2023, 12, 915. https://doi.org/10.3390/pathogens12070915

AMA Style

Zidovec-Lepej S, Batovic M, Rozman M, Bodulić K, Prtorić L, Šokota A, Nikcevic A, Simicic P, Tešović G. Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters. Pathogens. 2023; 12(7):915. https://doi.org/10.3390/pathogens12070915

Chicago/Turabian Style

Zidovec-Lepej, Snjezana, Margarita Batovic, Marija Rozman, Kristian Bodulić, Laura Prtorić, Ante Šokota, Andrea Nikcevic, Petra Simicic, and Goran Tešović. 2023. "Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters" Pathogens 12, no. 7: 915. https://doi.org/10.3390/pathogens12070915

APA Style

Zidovec-Lepej, S., Batovic, M., Rozman, M., Bodulić, K., Prtorić, L., Šokota, A., Nikcevic, A., Simicic, P., & Tešović, G. (2023). Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters. Pathogens, 12(7), 915. https://doi.org/10.3390/pathogens12070915

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop