Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates of Mannheimia haemolytica and Pasteurella multocida

Blondeau, Joseph M.; Fitch, Shantelle D.

doi:10.3390/pathogens13050399

Open AccessArticle

Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates of Mannheimia haemolytica and Pasteurella multocida

by

Joseph M. Blondeau

^1,2,*

and

Shantelle D. Fitch

¹

Department of Clinical Microbiology, Royal University Hospital and Saskatchewan Health Authority, Saskatoon, SK S7N 0W8, Canada

²

Department of Biochemistry, Microbiology and Immunology, Pathology and Laboratory Medicine and Ophthalmology, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada

^*

Author to whom correspondence should be addressed.

Pathogens 2024, 13(5), 399; https://doi.org/10.3390/pathogens13050399

Submission received: 16 April 2024 / Revised: 2 May 2024 / Accepted: 6 May 2024 / Published: 9 May 2024

(This article belongs to the Section Bacterial Pathogens)

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Abstract

Pradofloxacin—a dual-targeting fluoroquinolone—is the most recent approved for use in food animals. Minimum inhibitory and mutant prevention concentration values were determined for pradofloxacin, ceftiofur, enrofloxacin, florfenicol, marbofloxacin, tildipirosin, tilmicosin, and tulathromycin. For M. haemolytica strains, MIC_50/90/100 values were ≤0.016/≤0.016/≤0.016 and MPC_50/90/100 values were 0.031/0.063/0.063; for P. multocida strains, the MIC_50/90/100 values ≤0.016/≤0.016/0.031 and MPC_50/90/100 ≤ 0.016/0.031/0.063 for pradofloxacin. The pradofloxacin C_max/MIC₉₀ and C_max/MPC₉₀ values for M. haemolytica and P. multocida strains, respectively, were 212.5 and 53.9 and 212.5 and 109.7. Similarly, AUC₂₄/MIC₉₀ and AUC₂₄/MPC₉₀ for M. haemolytica were 825 and 209.5, and for P. multocida, they were 825 and 425.8. Pradofloxacin would exceed the mutant selection window for >12–16 h. Pradofloxacin appears to have a low likelihood for resistance selection against key bovine respiratory disease bacterial pathogens based on low MIC and MPC values.

Keywords: Mannheimia haemolytica; Pasteurella multocida; MIC/MPC; pradofloxacin

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MDPI and ACS Style

Blondeau, J.M.; Fitch, S.D. Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates of Mannheimia haemolytica and Pasteurella multocida. Pathogens 2024, 13, 399. https://doi.org/10.3390/pathogens13050399

AMA Style

Blondeau JM, Fitch SD. Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates of Mannheimia haemolytica and Pasteurella multocida. Pathogens. 2024; 13(5):399. https://doi.org/10.3390/pathogens13050399

Chicago/Turabian Style

Blondeau, Joseph M., and Shantelle D. Fitch. 2024. "Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates of Mannheimia haemolytica and Pasteurella multocida" Pathogens 13, no. 5: 399. https://doi.org/10.3390/pathogens13050399

APA Style

Blondeau, J. M., & Fitch, S. D. (2024). Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates of Mannheimia haemolytica and Pasteurella multocida. Pathogens, 13(5), 399. https://doi.org/10.3390/pathogens13050399

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested against Bovine Isolates of Mannheimia haemolytica and Pasteurella multocida

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