Glomerular Injury Is Associated with Severe Courses of Orthohantavirus Infection
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Enzyme-Linked Immunosorbent Assay (ELISA)
2.3. Statistical Analysis
3. Results
3.1. Levels of Glomerular and Tubular Injury Markers in Patients with HFRS
3.2. Course of Levels of KIM-1 in HFRS
3.3. Correlation of Tubular and Glomerular Injury with Disease Severity
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All Patients (n = 22) Median (Range) | Moderate (n = 14) Median (Range) | Severe (n = 8) Median (Range) | p Value | |
---|---|---|---|---|
Gender (male/female) | 18/4 | 11/3 | 7/1 | 1.000 |
Age (years) | 34 (22–61) | 36.5 (22–61) | 33.5 (24–44) | 0.3524 |
LOS (days) | 5 (3–15) | 4.5 (3–5) | 8 (6–15) | 0.0001 *** |
SCremax (mg/dL) | 5.41 (1.93–18.02) | 4.820 (1.930–9.630) | 9.935 (2.270–18.02) | 0.0027 ** |
SAlbmin (g/L) | 35.10 (22.7–42.30) | 36.10 (33.40–42.30) | 33.3 (22.7–36.8) | 0.0098 ** |
Plateletsmin (109/L) | 110.5 (21–291) | 135 (55–291) | 75.5 (21–154) | 0.0220 * |
Leukocytesmax (109/L) | 10.33 (4.92–14.54) | 10.61 (5.36–14.54) | 9.28 (4.92–11.67) | 0.2295 |
Proteinuriamax (g/L) | 3.519 (0.109–16.93) | 1.286 (0.109–9.831) | 4.217 (0.2490–16.93) | 0.0474 * |
LDHmax (U/L) | 385 (262–514) | 372 (262–500) | 414 (269–514) | 0.7662 |
CRPmax (mg/L) | 59.95 (17.2–150.1) | 54.65 (17.2–141.3) | 68.25 (29.8–150.1) | 0.4306 |
Adm dpo (days) | 6 (3–9) | 6 (4–9) | 6 (3–7) | 0.3740 |
Nephrinadm (ng/mL) | 141.6 (10.3–2571) | 95.49 (10.3–475.6) | 411.9 (172.7–2571) | 0.0020 ** |
IgGadm (mg/L) | 455.0 (4.1–3620) | 194 (4.1–1540) | 643 (268–3620) | 0.0140 * |
KIM-1adm (ng/mL) | 3.91 (1.084–10.66) | 3.135 (1.084–10.66) | 5.033 (1.193–8.503) | 0.1087 |
α1-MGadm (mg/L) | 24.85 (6.2–127) | 20.3 (7.2–42) | 31.3 (6.2–127) | 0.2673 |
Parameter | KIM-1adm (ng/mL) | Nephrinadm (ng/mL) | ||||
---|---|---|---|---|---|---|
R | CI | p Value | R | CI | p Value | |
Age (years) | −0.3144 | −0.6576–0.1367 | 0.1541 | −0.0393 | −0.4845–0.4221 | 0.8695 |
LOS (days) | 0.2014 | −0.2533–0.5831 | 0.3688 | 0.8715 | 0.6982–0.9483 | <0.0001 **** |
SCremax (mg/dL) | 0.1846 | −0.2694–0.5716 | 0.4107 | 0.6947 | 0.3518–0.8732 | 0.0007 *** |
Proteinuriamax (g/L) | 0.1790 | −0.2749–0.5676 | 0.4254 | 0.7616 | 0.4812–0.9006 | <0.0001 **** |
LDHmax (U/L) | 0.0311 | −0.4070–0.4575 | 0.8909 | 0.0887 | −0.3804–0.5216 | 0.7099 |
CRPmax (mg/L) | 0.1248 | −0.3253–0.5288 | 0.5800 | 0.4466 | −0.0091− 0.7487 | 0.0484 * |
Plateletsmin (109/L) | 0.1243 | −0.3258–0.5285 | 0.5816 | −0.5515 | −0.8041–−0.1303 | 0.0117 * |
Leukocytesmax (109/L) | −0.1722 | −0.5629–0.2813 | 0.4434 | −0.0165 | −0.4669–0.4406 | 0.9448 |
SAlbmin (g/L) | 0.1767 | −0.2770–0.5660 | 0.4314 | −0.4556 | −0.7536–−0.0023 | 0.0435 * |
Nephrinadm (ng/mL) | 0.2496 | −0.2303–0.6319 | 0.2885 | − | − | - |
Parameter | α1-MGadm (mg/L) | IgGadm (mg/L) | ||||
---|---|---|---|---|---|---|
R | CI | p Value | R | CI | p Value | |
Age (years) | −0.3752 | −0.7084–0.0947 | 0.1030 | −0.2319 | −0.6204–0.2481 | 0.3253 |
LOS (days) | 0.3147 | −0.1623–0.6725 | 0.1765 | 0.7572 | 0.4621–0.9013 | 0.0001 *** |
SCremax (mg/dL) | 0.3714 | −0.0991–0.7062 | 0.1069 | 0.6311 | 0.2483–0.8434 | 0.0028 ** |
Proteinuriamax (g/L) | 0.4226 | −0.0387–0.7354 | 0.0634 | 0.9026 | 0.7601–0.9623 | <0.0001 **** |
LDHmax (U/L) | 0.2722 | −0.2073–0.6462 | 0.2457 | 0.2978 | −0.1668–0.6542 | 0.2022 |
CRPmax (mg/L) | 0.5684 | 0.1544–0.8126 | 0.0089 ** | 0.1136 | −0.3588–0.5396 | 0.6335 |
Plateletsmin (109/L) | −0.5546 | −0.8056–−0.1346 | 0.0112 * | −0.2853 | −0.6544–0.1936 | 0.2228 |
Leukocytesmax (109/L) | 0.5865 | 0.1807–0.8216 | 0.0066 ** | −0.0888 | −0.5216–0.3804 | 0.7098 |
SAlbmin (g/L) | −0.0211 | −0.4704–0.4370 | 0.9298 | −0.2181 | −0.6114–0.2616 | 0.3556 |
Nephrinadm (ng/mL) | 0.5519 | 0.1308–0.8043 | 0.0116 * | 0.7672 | 0.4808–0.9057 | <0.0001 **** |
KIM-1adm (ng/mL) | 0.3805 | −0.0887–0.7115 | 0.0980 | 0.2836 | −0.1954–0.6533 | 0.2257 |
IgGadm (mg/L) | 0.4332 | −0.0256–0.7413 | 0.0564 | − | − | − |
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Nusshag, C.; Uhrig, J.; Gruber, G.; Schreiber, P.; Zeier, M.; Krautkrämer, E. Glomerular Injury Is Associated with Severe Courses of Orthohantavirus Infection. Pathogens 2024, 13, 693. https://doi.org/10.3390/pathogens13080693
Nusshag C, Uhrig J, Gruber G, Schreiber P, Zeier M, Krautkrämer E. Glomerular Injury Is Associated with Severe Courses of Orthohantavirus Infection. Pathogens. 2024; 13(8):693. https://doi.org/10.3390/pathogens13080693
Chicago/Turabian StyleNusshag, Christian, Josephine Uhrig, Gefion Gruber, Pamela Schreiber, Martin Zeier, and Ellen Krautkrämer. 2024. "Glomerular Injury Is Associated with Severe Courses of Orthohantavirus Infection" Pathogens 13, no. 8: 693. https://doi.org/10.3390/pathogens13080693