The Clinical Pharmacology and Therapeutic Evaluation of Non-Steroidal Anti-Inflammatory Drugs in Adult Horses
1
Department of Biological Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA
2
Department of Large Animal Clinical Sciences, Virginia Maryland College of Veterinary Medicine, Blacksburg, VA 24061, USA
*
Author to whom correspondence should be addressed.
Animals 2023, 13(10), 1597; https://doi.org/10.3390/ani13101597
Submission received: 21 December 2022
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Revised: 19 April 2023
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Accepted: 21 April 2023
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Published: 10 May 2023
(This article belongs to the Section Equids)
Simple Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in equine practice for a variety of painful or inflammatory conditions. This review discusses the clinical pharmacology of NSAIDs in adult horses and methods of evaluating the therapeutic effect of these drugs in equine research.
Abstract
This review firstly examines the underlying pathophysiology of pain and inflammation associated with orthopedic disease and endotoxemia. Then, it reviews the clinical pharmacology (pharmacokinetics and pharmacodynamics) of both conventional and non-conventional NSAIDs in the adult horse, and finally provides an overview of different modalities to evaluate the therapeutic efficacy of NSAIDs in research.
Keywords:
NSAIDs; horses; clinical pharmacology; endotoxemia; osteoarthritis
