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Effect of Early Ciprofloxacin Administration on Growth Performance, Meat Quality, Food Safety, and Metabolomic Profiles in Xuashan Chickens
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Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
2
Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou 225009, China
*
Authors to whom correspondence should be addressed.
Animals 2024, 14(16), 2395; https://doi.org/10.3390/ani14162395 (registering DOI)
Submission received: 8 July 2024
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Revised: 6 August 2024
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Accepted: 14 August 2024
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Published: 18 August 2024
(This article belongs to the Section Animal Products)
Simple Summary
The widespread use of antibiotics in poultry production has raised public concerns about food safety and meat quality. This study investigated the effects of early ciprofloxacin use on Xueshan chickens, focusing on growth, meat quality, and metabolic changes. It was found that, while ciprofloxacin treatment did not affect overall chicken growth, it significantly altered meat quality characteristics, which may affect meat texture and preservability. Although ciprofloxacin residues were not detected in muscle, metabolic analyses revealed significant metabolic alterations, particularly in microbial and amino acid metabolism pathways. These findings emphasize that antibiotic use may have far-reaching effects on poultry product quality, involving not only direct meat quality changes but also complex metabolic reactions. This study provides new perspectives for understanding the role of antibiotics in poultry production, which is important for optimizing antibiotic-use strategies and ensuring food safety. The results may be an important reference for poultry producers, food safety regulators and consumers.
Abstract
To investigate the effects of early administration of ciprofloxacin (CIP) on Xueshan chickens, in this study Xueshan chickens were measured for growth performance, tested for drug residues, evaluated for meat quality, and muscle metabolism changes were explored using a non-target metabolomics approach. Experimental findings revealed that early CIP use did not significantly impact the overall growth rate of Xueshan chickens (p > 0.05). However, notable alterations in meat quality were observed: the CIP-treated group exhibited a significant decrease in muscle pH (pH1 and pH24) and a marked increase in drip loss and moisture content (p > 0.05). No CIP residues were detected in muscle tissue. Untargeted metabolomics analyses unveiled significant alterations in the metabolic profile of market-age chickens following CIP treatment. Both functional enrichment and metabolic network analyses indicated significant effects on the ko01120 (microbial metabolism in diverse environments) and ko00350 (tyrosine metabolism) pathways, implying that CIP treatment may influence chicken meat quality by modulating microbial communities and amino acid metabolism. This study provides a crucial foundation for understanding the impact of antibiotics on meat quality and metabolism in poultry production, offering scientific insights for optimizing antibiotic-use strategies and safeguarding poultry product quality.
Keywords:
ciprofloxacin; chicken; meat quality; metabolomics; WGCNA
