A Review on Mammary Tumors in Rabbits: Translation of Pathology into Medical Care
Abstract
:Simple Summary
Abstract
1. Introduction
2. Reproduction in Rabbits—A Brief Summary
3. Mammary Gland–Histology and Specific Features in Rabbits
4. Mammary Tumors in Rabbits
4.1. A Brief History
4.2. Reported Data and Open Questions
4.2.1. Anamnestic Data and Histopathological Features
Mammary Lesion | Reference | Reported Frequency |
---|---|---|
Non-neoplastic proliferative lesions | ||
Lobular hyperplasia | [11] | 2 of 124 rabbits |
[24] | 1 rabbit (case report) | |
[26] | 2 of 24 rabbits | |
[36] | 17 rabbits (case series) | |
Multiple cysts | [11] | 25 of 124 rabbits |
[26] | 10 of 24 rabbits | |
Dysplasia | [24] | 1 rabbit (case report) |
[37] | 9 rabbits (case series) | |
Fibroadenomatous hyperplasia | [38] | 20 rabbits (case series) |
Benign tumors | ||
Tubular adenoma | [10] | 3 of 109 rabbits |
[11] | 2 of 124 rabbits | |
Cystadenoma | [11] | 1 of 124 rabbits |
[26] | 3 of 24 rabbits with 2-3 adenomas | |
Complex adenoma | [10] | 1 of 109 rabbits |
Intraductal papilloma * | [10] | 8 of 109 rabbits |
[26] | 1 of 24 rabbits with 2 papillomas | |
Malignant tumors | ||
In situ carcinoma | [11] | 2 of 124 rabbits |
[26] | 1 of 24 rabbits | |
Adenocarcinoma (different histotypes) | [10] | 83 of 109 rabbits |
[11] | 119 of 124 rabbits | |
[24] | 1 rabbit (case report) | |
[26] | 13 of 24 rabbits, 1 with 2 tumors | |
Complex adenocarcinoma | [10] | 5 of 109 rabbits |
Adenosquamous carcinoma | [10] | 9 of 109 rabbits |
[26] | 2 of 24 rabbits | |
Matrix-producing carcinoma | [26] | 1 of 24 rabbits |
Anaplastic carcinoma | [10] | 3 of 109 rabbits |
Spindle-cell carcinoma | [10] | 1 of 109 rabbits |
Ductal carcinoma | [10] | 4 of 109 rabbits |
Malignant myoepithelioma | [23] | 1 rabbit (case report) |
Carcinosarcoma | [25] | 1 rabbit (case report) |
4.2.2. Molecular Features
4.2.3. Evidence for a Hormonal Influence?
5. Discussion
5.1. Prognostic Biomarker
5.2. The Rabbit as Animal Model for Breast Cancer in Women?
5.3. Treatment
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Schöniger, S.; Degner, S.; Jasani, B.; Schoon, H.-A. A Review on Mammary Tumors in Rabbits: Translation of Pathology into Medical Care. Animals 2019, 9, 762. https://doi.org/10.3390/ani9100762
Schöniger S, Degner S, Jasani B, Schoon H-A. A Review on Mammary Tumors in Rabbits: Translation of Pathology into Medical Care. Animals. 2019; 9(10):762. https://doi.org/10.3390/ani9100762
Chicago/Turabian StyleSchöniger, Sandra, Sophie Degner, Bharat Jasani, and Heinz-Adolf Schoon. 2019. "A Review on Mammary Tumors in Rabbits: Translation of Pathology into Medical Care" Animals 9, no. 10: 762. https://doi.org/10.3390/ani9100762