Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials

Round 1

Reviewer 1 Report

interesting information consistent with the fact that many of the single system diseases we label are more than single system

Author Response

Dear Reviewer,
    
Thank you very much for your review. All comments and suggestions from the reviewers have been included in the manuscript. English language and style was check by native speaker. 

Hopefully, the revised version of the manuscript, considering the above issues, would be found suitable for publication.
Authors

Reviewer 2 Report

Myasthenia Gravis (MG) is an auto-immune disorder of the neuromuscular junction causing myasthenia. Electromyographic stimulations and single muscle fiber electromyography are the primary methods in evaluating the abnormal neuromuscular transmission in MG patients. There are evidence that evoked potential responses may correspond to the clinical course of the MG disease. However, there are no definite proof that explains whether MG is associated with the dysfunctional or affected peripheral and central nervous systems.

In this study, authors attempted to study the evoked potential paraments such as (visual - VEP, brainstem auditory – BAEP, somatosensory - SEP) in the MG patients to evaluate the MG disease association with the peripheral and central nervous system aberrations. It is an important clinical study that provides the details that the presence of disturbances in the bioelectric activities in the central and peripheral nervous system of the MG patients.

The current study showed that altered evoked potential parameters were not only  associated with the MG but also involved afferent pathways of the peripheral and central nervous system.

The abstract section can be re-written. In the current abstract, it starts with what was done in this study. However, addressing the problem at first and then explaining why and what was done in the current study would help the readers in understanding the concept of this study.

The current will help the future MG related diagnosis, clinical outcomes and possible better treatment strategies.

Conclusion section can be improved by very briefly recapping the results and english grammer correction.

English proofreading is required.

Author Response

Dear Reviewer,
    
Thank you very much for your review. All comments and suggestions from the reviewers have been included in the manuscript. The abstract, including the conclusions, has been revised. English language and style was check by native speaker. 

Hopefully, the revised version of the manuscript, considering the above issues, would be found suitable for publication.
Authors

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.