Relationship between Cortical Thickness and EEG Alterations during Sleep in the Alzheimer’s Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Polysomnographic Recordings
2.3. Sleep EEG Analysis
2.4. MRI Acquisition and Processing
2.5. Statistical Analyses
3. Results
3.1. Cortical Thickness and Sigma Activity of NREM Sleep
3.2. Cortical Thickness and the EEG Slowing (Delta and Beta Activity) during REM Sleep
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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PSG Measure 1 | Mean | s.d. |
---|---|---|
SO latency (min) | 26.60 | 19.99 |
REM latency (min) | 87.03 | 49.04 |
WASO (min) | 74.71 | 44.46 |
N1 (%) | 7.05 | 6.37 |
N2 (%) | 74.33 | 6.95 |
N3 (%) | 0.56 | 1.28 |
REM (%) | 18.24 | 6.81 |
TBT (min) | 373.58 | 70.16 |
TST (min) | 268.87 | 76.22 |
SEI (%) | 71.40 | 13.00 |
ISA (#) | 19.74 | 12.14 |
MR Cortical Areas | Side | Sleep Index | EEG Cluster | r | p |
---|---|---|---|---|---|
Caudal middle frontal | L | REM Delta | Temporal | −0.62 | 0.0016 |
R | REM Delta | Temporal | −0.65 | 0.00073 | |
Entorhinal | L | NREM sigma | Frontopolar | −0.62 | 0.0017 |
L | NREM sigma | Frontal | −0.67 | 0.00048 | |
L | NREM sigma | Central | −0.62 | 0.0017 | |
Fusiform | R | REM Delta | Frontopolar | −0.63 | 0.00122 |
R | REM Delta | Temporal | −0.58 | 0.0035 | |
Lingual | R | REM Delta | Frontopolar | −0.66 | 0.00060 |
R | REM Delta | Temporal | −0.60 | 0.0027 | |
Precuneus | R | NREM sigma | Parietal | 0.55 | 0.0071 |
R | REM delta | Frontopolar | −0.62 | 0.0017 | |
R | REM delta | Temporal | −0.68 | 0.00035 | |
R | REM beta | Temporal | 0.52 | 0.012 | |
R | REM beta | Occipital | 0.53 | 0.0092 | |
Superior parietal | R | REM delta | Temporal | −0.60 | 0.0023 |
Mean thickness | R | REM delta | Frontopolar | −0.60 | 0.0027 |
R | REM delta | Temporal | −0.59 | 0.0028 |
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D’Atri, A.; Gorgoni, M.; Scarpelli, S.; Cordone, S.; Alfonsi, V.; Marra, C.; Ferrara, M.; Rossini, P.M.; De Gennaro, L. Relationship between Cortical Thickness and EEG Alterations during Sleep in the Alzheimer’s Disease. Brain Sci. 2021, 11, 1174. https://doi.org/10.3390/brainsci11091174
D’Atri A, Gorgoni M, Scarpelli S, Cordone S, Alfonsi V, Marra C, Ferrara M, Rossini PM, De Gennaro L. Relationship between Cortical Thickness and EEG Alterations during Sleep in the Alzheimer’s Disease. Brain Sciences. 2021; 11(9):1174. https://doi.org/10.3390/brainsci11091174
Chicago/Turabian StyleD’Atri, Aurora, Maurizio Gorgoni, Serena Scarpelli, Susanna Cordone, Valentina Alfonsi, Camillo Marra, Michele Ferrara, Paolo Maria Rossini, and Luigi De Gennaro. 2021. "Relationship between Cortical Thickness and EEG Alterations during Sleep in the Alzheimer’s Disease" Brain Sciences 11, no. 9: 1174. https://doi.org/10.3390/brainsci11091174