Cortical Thickness of the Orbitofrontal Cortex in Patients with Alcohol Use Disorder
Abstract
:1. Introduction
2. Methods
2.1. Subjects
2.2. Magnetic Resonance Imaging (MRI) Procedure
2.3. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Healthy Control Group (n = 17) | Patient Group (n = 15) | p | |
---|---|---|---|
Age (years) | 36.86 ± 11.03 | 32.52 ± 5.90 | 0.169 |
Handedness (right) | 17 | 15 | >0.05 |
Gender (female/male) | 2/15 | 1/14 | 0.548 |
Length of illness (years) | - | 16.60 ± 10.78 | |
HDRS scores | 7.1 ± 1.9 | 11.7 ± 3.0 | <0.001 |
MAST | - | 28.40 ± 12.51 | |
SADQ-C | - | 26.86 ± 14.83 | |
AUDIT | - | 23.93 ± 7.46 | |
Grey matter volume | 694.11 ± 44.13 | 668.00 ± 66.78 | 0.21 |
White matter volume | 616.17 ± 29.44 | 619.00 ± 45.98 | 0.83 |
Orbitofrontal cortex volumes (cm3) | |||
Left | 14.38 ± 1.13 | 12.53 ± 1.12 | <0.001 |
Right | 14.07 ± 1.09 | 12.07 ± 0.87 | <0.001 |
Orbitofrontal cortex thickness (mm) | |||
Left medial | 2.40 ± 0.13 | 2.57 ± 0.12 | <0.01 |
Left lateral | 1.46 ± 0.25 | 1.21 ± 0.16 | <0.01 |
Right medial | 2.35 ± 0.13 | 2.55 ± 0.13 | <0.001 |
Right lateral | 2.45 ± 0.14 | 2.61 ± 0.14 | <0.001 |
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Atmaca, M.; Tabara, M.F.; Koc, M.; Gurok, M.G.; Baykara, S.; Korkmaz, S.; Mermi, O. Cortical Thickness of the Orbitofrontal Cortex in Patients with Alcohol Use Disorder. Brain Sci. 2023, 13, 552. https://doi.org/10.3390/brainsci13040552
Atmaca M, Tabara MF, Koc M, Gurok MG, Baykara S, Korkmaz S, Mermi O. Cortical Thickness of the Orbitofrontal Cortex in Patients with Alcohol Use Disorder. Brain Sciences. 2023; 13(4):552. https://doi.org/10.3390/brainsci13040552
Chicago/Turabian StyleAtmaca, Murad, Muhammed Fatih Tabara, Mustafa Koc, Mehmet Gurkan Gurok, Sema Baykara, Sevda Korkmaz, and Osman Mermi. 2023. "Cortical Thickness of the Orbitofrontal Cortex in Patients with Alcohol Use Disorder" Brain Sciences 13, no. 4: 552. https://doi.org/10.3390/brainsci13040552