The Association between Long Non-Coding RNAs and Alzheimer’s Disease
Abstract
:1. Introduction
1.1. Significance of lncRNAs
1.2. Biological Functions of LncRNAs in Health and Disease
1.3. LncRNAs Dysregulation in Alzheimer’s Disease
1.4. LncRNAs as Potential Therapeutic Targets in Alzheimer’s Disease
1.5. Gender Specific lncRNAs in AD
1.6. LncRNA Therapy
1.7. Diagnostic Potential of LncRNAs in AD
2. Conclusions and Perspectives
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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LncRNA ID | Trend | Proposed Function | Reference(s) |
---|---|---|---|
MALAT1 | ↓ in AD | Inhibit neuronal apoptosis & neuroinflammation, neurite outgrowth stimulation | [17,51,52,53,54,55] |
NEAT1 | ↑ in AD | Limits Aβ production and ameliorates cognitive deficits | [21,56,57,58] |
MAPT1-AS | ↓ in AD | Inhibit tau translation by rRNA pairing | [59,60] |
SNHG8 | ↓ in AD | Interacts with TIA1, an RNA binding protein associated with tau and stress granules | [61] |
BACE1-AS | ↑ in AD | Amyloid precursor protein cleaving β-secretase → increased Aβ peptides | [18,20,21,62,63] |
LRP1-AS | ↑ in AD | Lowers LRP1’s expression, influencing Aβ agglomeration | [64] |
SORL1-AS | ↑ in AD | Creation of deleterious splicing isoforms of SORL1 → increase Aβ levels | [23] |
UCHL1-AS | ↓ in AD | Ubiquitinates Aβ protein → plaque deconstruction | [24] |
51A | ↑ in AD | Downregulates SORL1, Impaired processing of APP, increased Aβ formation | [5,35,65,66] |
BC200 | ↑ in AD | Regulating neuronal protein translation → amyloid plaque formation and AD pathogenesis | [21,67,68,69] |
NAT-Rad18 | ↑ in AD | Increases neuronal apoptosis by lowering neuronal DNA damage compensatory abilities | [25,70] |
NDM29 | ↑ in AD | Increased Aβ peptides | [71] |
SOX2-OT | ↓ in AD | Promotes neurogenesis and neuronal differentiation | [66,72,73] |
SNHG1 | ↑ in AD | Regulate neuroinflammation, DNA methylation and apoptosis | [74,75,76,77] |
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Black, C.M.; Braden, A.A.; Nasim, S.; Tripathi, M.; Xiao, J.; Khan, M.M. The Association between Long Non-Coding RNAs and Alzheimer’s Disease. Brain Sci. 2024, 14, 818. https://doi.org/10.3390/brainsci14080818
Black CM, Braden AA, Nasim S, Tripathi M, Xiao J, Khan MM. The Association between Long Non-Coding RNAs and Alzheimer’s Disease. Brain Sciences. 2024; 14(8):818. https://doi.org/10.3390/brainsci14080818
Chicago/Turabian StyleBlack, Carson M., Anneliesse A. Braden, Samia Nasim, Manish Tripathi, Jianfeng Xiao, and Mohammad Moshahid Khan. 2024. "The Association between Long Non-Coding RNAs and Alzheimer’s Disease" Brain Sciences 14, no. 8: 818. https://doi.org/10.3390/brainsci14080818