Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection
Abstract
1. Introduction
2. Surgical Techniques, Indications, and Outcomes
2.1. Spinoplastic Techniques and Approaches
2.1.1. Iliac Crest VBG
2.1.2. Scapular VBG
2.1.3. Rib VBG
2.1.4. Occipital VBG
2.1.5. Spinous Process VBG
2.1.6. Clavicular VBG
VBG Type | Blood Supply | Surgical Complexity | Complication Rate | Appropriate Clinical Scenario |
---|---|---|---|---|
IC-VBG | Quadratus lumborum | Moderate | Low | Posterolateral spinal reconstruction from T12-S1 |
S-VBG | Transverse cervical artery | Moderate-high | Low-moderate | Posterior cervical-thoracic reconstruction from the occiput to T8 |
R-VBG | Intercostal vessels | Moderate | Low-moderate | Posterior spinal defects with rib curvature alignment * |
O-VBG | Deep cervical artery | High | Moderate | Posterior cervical reconstruction from C1 to T1 |
SP-VBG | Paraspinal muscles | Moderate | Low-moderate | Posterolateral fusion augmentation, can be utilized from the occiput to T8 |
C-VBG | Occipital & superior thyroid artery | Very high | High | Anterior cervicothoracic reconstruction from C2 to T2 |
2.2. Indications, Goals, and Identification of Suitable Candidates
2.3. Contraindications, Risks, and Potiential Pitfalls
2.4. Review of Published VBG Cases to Date
3. Discussion
4. Conclusions
5. Future Directions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
- Martinez, C.; Abdulwadood, I.; Gomez, D.A.; Jeger, J.; Bakri, K.; Bohl, M.; Ropper, A.E.; Winocour, S.; Reece, E.M. Spino-plastic surgery. Orthoplast. Surg. 2024, 18, 2–7. [Google Scholar] [CrossRef]
- Skochdopole, A.J.; Wagner, R.D.; Davis, M.J.; Raj, S.; Winocour, S.J.; Ropper, A.E.; Xu, D.S.; Bohl, M.A.; Reece, E.M. Vascularized Bone Grafts in Spinal Reconstruction: An Overview of Nomenclature and Indications. Semin. Plast. Surg. 2021, 35, 50–53. [Google Scholar] [CrossRef]
- Hallock, G.G. The Complete Nomenclature for Combined Perforator Flaps. Plast. Reconstr. Surg. 2011, 127, 1720–1729. [Google Scholar] [CrossRef]
- Picetti, E.; Iaccarino, C.; Servadei, F. Letter: Guidelines for the Management of Severe Traumatic Brain Injury Fourth Edition. Neurosurg. 2017, 81, E2. [Google Scholar] [CrossRef] [PubMed]
- Ou, Q.; Wu, P.; Zhou, Z.; Pan, D.; Tang, J.Y. Complication of osteo reconstruction by utilizing free vascularized fibular bone graft. BMC Surg. 2020, 20, 216. [Google Scholar] [CrossRef]
- Winters, H.A.H.; van Engeland, A.E.; Jiya, T.U.; van Royen, B.J. The use of free vascularised bone grafts in spinal re-construction. J. Plast. Reconstr. Aesthetic Surg. 2010, 63, 516–523. [Google Scholar] [CrossRef] [PubMed]
- Bambakidis, N.C.; Feiz-Erfan, I.; Klopfenstein, J.D.; Sonntag, V.K. Indications for surgical fusion of the cervical and lumbar motion segment. Spine 2005, 30 (Suppl. S16), S2–S6. [Google Scholar] [CrossRef] [PubMed]
- Leven, D.; Cho, S.K. Pseudarthrosis of the Cervical Spine: Risk Factors, Diagnosis and Management. Asian Spine J. 2016, 10, 776–786. [Google Scholar] [CrossRef]
- Reece, E.M.; Agrawal, N.; Wagner, K.M.; Davis, M.J.; Abu-Ghname, A.; Shekher, R.; Raber, M.R.; Winocour, S.; Bohl, M.A.; Ropper, A.E. Vascularized Bone Grafts for Spinal Fusion-Part 2: The Rib. Oper. Neurosurg. 2021, 20, 497–501. [Google Scholar] [CrossRef]
- Nasser, R.; Yadla, S.; Maltenfort, M.G.; Harrop, J.S.; Anderson, D.G.; Vaccaro, A.R.; Sharan, A.D.; Ratliff, J.K. Complications in spine surgery: A review. J. Neurosurg. Spine 2010, 13, 144–157. [Google Scholar] [CrossRef]
- Chun, D.S.; Baker, K.C.; Hsu, W.K. Lumbar pseudarthrosis: A review of current diagnosis and treatment. Neurosurg. Focus 2015, 39, E10. [Google Scholar] [CrossRef]
- Gruskay, J.A.; Webb, M.L.; Grauer, J.N. Methods of evaluating lumbar and cervical fusion. Spine J. 2014, 14, 531–539. [Google Scholar] [CrossRef] [PubMed]
- Irmola, T.M.; Häkkinen, A.; Järvenpää, S.; Marttinen, I.; Vihtonen, K.; Neva, M. Reoperation Rates Following Instrumented Lumbar Spine Fusion. Spine 2018, 43, 295–301. [Google Scholar] [CrossRef] [PubMed]
- Raizman, N.M.; O’Brien, J.R.; Poehling-Monaghan, K.L.; Yu, W.D. Pseudarthrosis of the spine. J. Am. Acad. Orthop. Surg. 2009, 17, 494–503. [Google Scholar] [CrossRef] [PubMed]
- Turner, J.A.; Ersek, M.; Herron, L.; Haselkorn, J.; Kent, D.; Ciol, M.A.; Deyo, R. Patient outcomes after lumbar spinal fusions. JAMA 1992, 268, 907–911. [Google Scholar] [CrossRef]
- Heck, V.J.; Klug, K.; Prasse, T.; Oikonomidis, S.; Klug, A.; Himpe, B.; Egenolf, P.; Lenz, M.; Eysel, P.; Scheyerer, M.J. Projections from Surgical Use Models in Germany Suggest a Rising Number of Spinal Fusions in Patients 75 Years and Older Will Challenge Healthcare Systems Worldwide. Clin. Orthop. Relat. Res. 2023, 481, 1610–1619. [Google Scholar] [CrossRef]
- Neifert, S.N.; Martini, M.L.; Yuk, F.; McNeill, I.T.; Caridi, J.M.; Steinberger, J.; Oermann, E.K. Predicting Trends in Cervical Spinal Surgery in the United States from 2020 to 2040. World Neurosurg. 2020, 141, e175–e181. [Google Scholar] [CrossRef]
- Dolan, R.T.; Butler, J.S.; Wilson-MacDonald, J.; Reynolds, J.; Cogswell, L.; Critchley, P.; Giele, H. Quality of Life and Surgical Outcomes After Soft-Tissue Reconstruction of Complex Oncologic Defects of the Spine and Sacrum. J. Bone Jt. Surg. Am. 2016, 98, 117–126. [Google Scholar] [CrossRef]
- Etminan, M.; Girardi, F.P.; Khan, S.N.; Cammisa, F.P., Jr. Revision strategies for lumbar pseudarthrosis. Orthop. Clin. N. Am. 2002, 33, 381–392. [Google Scholar] [CrossRef]
- Sherif, S.; Arlet, V. Revision surgery for non-union in adult spinal deformity. Eur. Spine J. 2020, 29 (Suppl. S1), 103–115. [Google Scholar] [CrossRef]
- Jeger, J.L.; Martinez, C.J.; Shvedova, M.; Simoni, A.; Rebecca, A.; Winocour, S.; Ropper, A.E.; Bohl, M.; Casey, W.J., 3rd; Kalani, M.; et al. Vascularized Iliac Crest Bone Graft for the Reconstruction of Anterior Vertebral Corpus Defects: A Literature Review and Cadaveric Feasibility Study. Plast. Reconstr. Surg. Glob. Open 2025, 13, e6380. [Google Scholar] [CrossRef] [PubMed]
- Reece, E.M.; Davis, M.J.; Wagner, R.D.; Abu-Ghname, A.; Cruz, A.; Kaung, G.; Verla, T.; Winocour, S.; Ropper, A.E. Vascularized Bone Grafts for Spinal Fusion-Part 1: The Iliac Crest. Oper. Neurosurg. 2021, 20, 493–496. [Google Scholar] [CrossRef] [PubMed]
- Paracha, U.; Hendrix, J.M. Cluneal Neuralgia. In StatPearls; StatPearls Publishing Copyright © 2025; StatPearls Publishing LLC.: Treasure Island, FL, USA, 2025. [Google Scholar]
- Reece, E.M.; Davis, M.J.; Abu-Ghname, A.; Chamata, E.; Holmes, S.; Winocour, S.; Hansen, S.L.; Xu, D.S.; Bohl, M.A.; Ropper, A.E. Vascularized Bone Grafts for Spinal Fusion-Part 4: The Scapula. Oper. Neurosurg. 2021, 20, 508–512. [Google Scholar] [CrossRef]
- Winocour, S.J.; Agrawal, N.; Wagner, K.M.; Davis, M.J.; Abu-Ghname, A.; Shekher, R.; Raber, M.R.; Bohl, M.A.; Ropper, A.E.; Reece, E.M. Vascularized Rib Bone Grafting: Indications, Techniques, and Clinical Outcomes. Semin. Plast. Surg. 2021, 35, 31–36. [Google Scholar] [CrossRef] [PubMed]
- Bohl, M.A.; Almefty, K.K.; Preul, M.C.; Turner, J.D.; Kakarla, U.K.; Reece, E.M.; Chang, S.W. Vascularized Spinous Process Graft Rotated on a Paraspinous Muscle Pedicle for Lumbar Fusion: Technique Description and Early Clinical Experience. World Neurosurg. 2018, 115, 186–192. [Google Scholar] [CrossRef]
- Bohl, M.A.; Mooney, M.A.; Catapano, J.S.; Almefty, K.K.; Preul, M.C.; Chang, S.W.; Kakarla, U.K.; Reece, E.M.; Turner, J.D.; Porter, R.W. Pedicled Vascularized Clavicular Graft for Anterior Cervical Arthrodesis: Cadaveric Feasibility Study, Technique Description, and Case Report. Spine 2017, 42, E1266–E1271. [Google Scholar] [CrossRef]
- Winocour, S.J.; Schultz, K.P.; Davis, M.J.; Abu-Ghname, A.; Bohl, M.; Ropper, A.E.; Maricevich, M.; Reece, E.M. Vascularized Posterior Iliac Crest Bone Grafting: Indications, Techniques, Clinical Outcomes, and Alternatives. Semin. Plast. Surg. 2021, 35, 37–40. [Google Scholar] [CrossRef]
- Boonsirikamchai, W.; Wilartratsami, S.; Ruangchainikom, M.; Korwutthikulrangsri, E.; Tongsai, S.; Luksanapruksa, P. Pseudarthrosis risk factors in lumbar fusion: A systematic review and meta-analysis. BMC Musculoskelet. Disord. 2024, 25, 433. [Google Scholar] [CrossRef]
- Hofler, R.C.; Swong, K.; Martin, B.; Wemhoff, M.; Jones, G.A. Risk of Pseudoarthrosis After Spinal Fusion: Analysis from the Healthcare Cost and Utilization Project. World Neurosurg. 2018, 120, e194–e202. [Google Scholar] [CrossRef]
- How, N.E.; Street, J.T.; Dvorak, M.F.; Fisher, C.G.; Kwon, B.K.; Paquette, S.; Smith, J.S.; Shaffrey, C.I.; Ailon, T. Pseudarthrosis in adult and pediatric spinal deformity surgery: A systematic review of the literature and meta-analysis of incidence, characteristics, and risk factors. Neurosurg. Rev. 2019, 42, 319–336. [Google Scholar] [CrossRef]
- Shahzad, H.; Ahmad, M.; Singh, V.K.; Bhatti, N.; Yu, E.; Phillips, F.M.; Khan, S.N. Predictive factors of symptomatic lumbar pseudoarthrosis following multilevel primary lumbar fusion. N. Am. Spine Soc. J. 2024, 17, 100302. [Google Scholar] [CrossRef] [PubMed]
- Wang, Z.; Wang, J.; Jin, C.; Zhan, X.; Li, Y.; Xiang, Q.; Wang, K.; Ni, H.; Dai, T.; Yu, Y.; et al. Development and Validation of a Risk Prediction Model for Pseudarthrosis Following Transforaminal Lumbar Interbody Fusion: A Retrospective Analysis. World Neurosurg. 2025, 193, 636–646. [Google Scholar] [CrossRef] [PubMed]
- Jain, N.; Himed, K.; Toth, J.M.; Briley, K.C.; Phillips, F.M.; Khan, S.N. Opioids delay healing of spinal fusion: A rabbit posterolateral lumbar fusion model. Spine J. 2018, 18, 1659–1668. [Google Scholar] [CrossRef] [PubMed]
- Ekşi, M.Ş.; Tanriverdi, N.; Topaloğlu, F.; Duymaz, U.C.; Yeşilyurt, S.C.; Bektaşoğlu, P.K.; Öztürk, Ö.Ç.; Börekci, A.; Hazneci, J.; Topçu, A.; et al. Higher charlson comorbidity index score correlates with higher rate of pseudoarthrosis following short-segment lumbar fusion surgery. Eur. Spine J. 2025, 34, 215–224. [Google Scholar] [CrossRef]
- Archual, A.J.; Bishop, A.T.; Shin, A.Y. Vascularized Bone Grafts in Orthopaedic Surgery: A Review of Options and Indications. J. Am. Acad. Orthop. Surg. 2022, 30, 60–69. [Google Scholar] [CrossRef]
- Shvedova, M.; Abdulwadood, I.; Vernik, D.M.; Shrout, M.A.; Jeger, J.L.; Buchanan, D.C.; Ropper, A.; Winocour, S.; Bohl, M.; Kalani, M.A.; et al. Novel Approach to Difficult Spinal Reconstruction: Bilateral Simultaneous Rib and Iliac Crest Vascularized Bone Graft Spinoplastic Surgery. Plast. Reconstr. Surg. Glob. Open 2024, 12, e5656. [Google Scholar] [CrossRef]
- Cohen, L.E.; Fullerton, N.; Mundy, L.R.; Weinstein, A.L.; Fu, K.M.; Ketner, J.J.; Härtl, R.; Spector, J.A. Optimizing Successful Outcomes in Complex Spine Reconstruction Using Local Muscle Flaps. Plast. Reconstr. Surg. 2016, 137, 295–301. [Google Scholar] [CrossRef]
- Shin, E.H.; Shin, A.Y. Vascularized Bone Grafts in Orthopaedic Surgery. JBJS Rev. 2017, 5, e1. [Google Scholar] [CrossRef]
- Christine, V.S.; John, T.S. Tackling bone loss of the lower extremity: Vascularized bone grafting. Plast. Aesthetic Res. 2022, 9, 27. [Google Scholar] [CrossRef]
- Gu, Y.; Ma, H.; Shujaat, S.; Orhan, K.; Coucke, W.; Amoli, M.S.; Bila, M.; Politis, C.; Jacobs, R. Donor- and recipient-site morbidity of vascularized fibular and iliac flaps for mandibular reconstruction: A systematic review and meta-analysis. J. Plast. Reconstr. Aesthet. Surg. 2021, 74, 1470–1479. [Google Scholar] [CrossRef]
- Pirela-Cruz, M.A.; DeCoster, T.A. Vascularized bone grafts. Orthopedics 1994, 17, 407–412. [Google Scholar] [CrossRef] [PubMed]
- Reece, E.M.; Raghuram, A.C.; Bartlett, E.L.; Lazaro, T.T.; North, R.Y.; Bohl, M.A.; Ropper, A.E. Vascularized Iliac Bone Graft for Complex Closure During Spinal Deformity Surgery. Plast. Reconstr. Surg. Glob. Open 2019, 7, e2345. [Google Scholar] [CrossRef] [PubMed]
- Bohl, M.A.; Reece, E.M.; Farrokhi, F.; Davis, M.J.; Abu-Ghname, A.; Ropper, A.E. Vascularized Bone Grafts for Spinal Fusion-Part 3: The Occiput. Oper. Neurosurg. 2021, 20, 502–507. [Google Scholar] [CrossRef] [PubMed]
- Reece, E.M.; Van Spronsen, N.; Velluto, C.; Jeger, J.L.; Fullmer, C.; Abdulwadood, I.; Meyer, J.; Ropper, A.E.; Winocour, S.; Bohl, M.A.; et al. Spinoplastic Reconstruction Using Iliac Crest Vascularized Bone Graft following Sacral Ependymoma Resection. Plast. Reconstr. Surg. Glob. Open 2024, 12, e6341. [Google Scholar] [CrossRef]
- Riasa, I.N.P.; Reece, E.M.; Mahadewa, T.G.B.; Kawilarang, B.; Jeger, J.L.; Awyono, S.; Putra, M.B.; Putra, K.K.; Suadnyana, I.P.R. Occipital Vascularized Bone Graft for Reconstruction of a C3-C7 Defect. Plast. Reconstr. Surg. Glob. Open 2024, 12, e6268. [Google Scholar] [CrossRef]
Indications |
Previous fusion failures or pseudoarthrosis |
Severe spinal deformities |
Extensive oncological resections |
Elevated infection risk |
Impaired bone healing conditions (e.g., radiation therapy, diabetes, chronic steroid use, active smoking) |
Extensive spinal involvement requiring augmented support |
Authors (Year) | Study Type | Number of Patients | VBG(s) Utilized | Level of Evidence | Clinical Variables | Primary Clinical Outcomes |
---|---|---|---|---|---|---|
Reece et al. (2021) [22] | Case Series | 14 | IC-VBG | IV | IC-VBG in high-risk lumbar fusions | Successful graft fusion, no complications |
Reece et al. (2021) [24] | Case Report | 1 | S-VBG | V | S-VBG for smoker with cervical kyphosis and prior radiation | Improved kyphosis, no graft complications |
Reece et al. (2019) [43] | Case Report | 1 | R-VBG | V | R-VBG for paraplegic with prior fusion failure | Improved stability, no pseudoarthrosis |
Bohl et al. (2021) [44] | Case Series | 2 | O-VBG | IV | O-VBG for failed prior cervical fusion | Successful fusion despite complications |
Bohl et al. (2018) [26] | Case Series | 4 | SP-VBG | IV | SP-VBG for high risk lumbar fusion | Improved function; 1 fusion failure |
Bohl et al. (2017) [27] | Case Report | 1 | C-VBG | V | C-VBG for cervical myeloradiculopathy | Fusion success and symptomatic improvement despite significant complications requiring reoperation. |
Reece et al. (2024) [45] | Case Report | 1 | IC-VBG | V | IC-VBG for extensive oncolological resection | Imaging demonstrated succesful placement of VBG. Follow-up data limited. |
Shvedova et al. (2024) [37] | Case Report | 1 | R-VBG, IC-VBG | V | Bilateral Rib & IC-VBG for severe kyphosis | Successful fusion, improvement of symptoms |
Riasa et al. (2024) [46] | Case Report | 1 | O-VBG | V | O-VBG in resource-limited setting | Succesful fusion and imrpovement of symptoms despite limited resources |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Vernik, D.; Payne, C.; Sinha, K.; Martinez, C.; Jungbauer, W.N.; Jeger, J.L.; Bohl, M.; Ropper, A.E.; Winocour, S.; Reece, E. Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection. Brain Sci. 2025, 15, 705. https://doi.org/10.3390/brainsci15070705
Vernik D, Payne C, Sinha K, Martinez C, Jungbauer WN, Jeger JL, Bohl M, Ropper AE, Winocour S, Reece E. Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection. Brain Sciences. 2025; 15(7):705. https://doi.org/10.3390/brainsci15070705
Chicago/Turabian StyleVernik, Daniel, Camryn Payne, Krishna Sinha, Casey Martinez, Walter Nicholas Jungbauer, Jonathan L. Jeger, Michael Bohl, Alexander E. Ropper, Sebastian Winocour, and Edward Reece. 2025. "Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection" Brain Sciences 15, no. 7: 705. https://doi.org/10.3390/brainsci15070705
APA StyleVernik, D., Payne, C., Sinha, K., Martinez, C., Jungbauer, W. N., Jeger, J. L., Bohl, M., Ropper, A. E., Winocour, S., & Reece, E. (2025). Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection. Brain Sciences, 15(7), 705. https://doi.org/10.3390/brainsci15070705