Neurophysiological Characterization of Thalamic Nuclei in Epileptic Anaesthetized Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Surgery
2.2. Somatosensory Evoked Potentials
2.3. Reconstruction of the Trajectory
2.4. Analysis of Discharge Properties
- Amplitude of the AP, measured from peak to peak (in µV). This property is not a tonic property, but is commonly used in clinical practice; therefore, we included it in this group.
- Mean frequency and standard deviation of the raw trace and for every neuron. Both values were obtained from the inverse of the instant frequency.
- Density, defined as the number of cells recorded by every electrode at one position. AP sorting was performed by clustering by using the Mahalanobis distances (see below) of several properties of the AP (e.g., amplitude and duration of positive and negative phases and maximum and minimum value of the first derivative). The maximum number of cells allowed to be identified by this mean was chosen as 5.
- Probability density functions (pdf) of the inter-spike interval (ISI) for every neuron. Relative frequency was computed for 1 ms bins, and the probability/bin (pi) was calculated with the following expression:
- Burst index (BI) is defined as the ratio between the number of ISI < 10 ms and the number of ISIs > 10 ms. It represents the number of bursts of discharges with respect to individual discharges, and is calculated as follows:
- Pause index (PI), defined as the ratio between the number of ISIs > 50 ms and the number of ISIs < 50 ms, is calculated as follows:
- Pause ratio (PR), defined as the total duration of pauses (ISI > 50 ms) divided by the total duration of no-pauses (ISI < 50 ms). Although similar in name, the information obtained is different from that of the PI, and the PR is calculated as follows:
2.5. Evaluation of Global Similarity
2.6. Statistics
3. Results
Tonic Properties
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
Appendix B
Nucleus | r | α | β | γ | δ | ε |
---|---|---|---|---|---|---|
Ce.pc | 0.9939 | 0.001 | 0.1296 | 0.5683 | 0.0135 | 0.0421 |
Ce.mc | 0.9904 | 0.001 | 0.0363 | 0.2660 | 0.0090 | 0.0285 |
V.im | 0.9929 | 0.0013 | 0.0429 | 0.7841 | 0.0193 | 0.0692 |
V.c | 0.9925 | 0.001 | 0.0356 | 0.2899 | 0.0085 | 0.0262 |
Appendix C
Index | Pair of Thresholds (ms) | Linear Function [y(x)] | r2 | t | p |
---|---|---|---|---|---|
10/50 | 0.675 | 2.038 | n.s | ||
BI | 20/100 | 0.040 | 0.289 | n.s | |
50/200 | 0.513 | 1.451 | n.s | ||
10/50 | 0.932 | 5.215 | <0.01 | ||
PI | 20/100 | 0.849 | 3.347 | <0.05 | |
50/200 | 0.980 | 9.900 | <0.001 | ||
10/50 | 0.933 | 5.261 | <0.01 | ||
PR | 20/100 | 0.757 | 2.496 | n.s | |
50/200 | 0.602 | 1.739 | n.s |
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Pat. | Sex | Age (years) | History (years) | Etiology | v-EEG | MRI Result | VNS | AED |
---|---|---|---|---|---|---|---|---|
1 | F | 37 | 31 | Genetic 1 | GE | Normal | Yes | PGB, CBZ, CNZ |
2 | F | 18 | 12 | LGS | GE | Dysplasia LF | No | RUF, VPT |
3 | M | 34 | 27 | Genetic 2 | EG/EE | Normal | Yes | VPT, PGB, LAC, ZNS |
4 | M | 27 | 27 | LGS | GE | Normal | No | LVZ, OXC, LAC, CZM |
5 | M | 30 | 23 | Structural | GE/EE | Dysplasia biFT | Yes | TPM, VPT |
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Vega-Zelaya, L.; Torres, C.V.; Navas, M.; Pastor, J. Neurophysiological Characterization of Thalamic Nuclei in Epileptic Anaesthetized Patients. Brain Sci. 2019, 9, 312. https://doi.org/10.3390/brainsci9110312
Vega-Zelaya L, Torres CV, Navas M, Pastor J. Neurophysiological Characterization of Thalamic Nuclei in Epileptic Anaesthetized Patients. Brain Sciences. 2019; 9(11):312. https://doi.org/10.3390/brainsci9110312
Chicago/Turabian StyleVega-Zelaya, Lorena, Cristina V. Torres, Marta Navas, and Jesús Pastor. 2019. "Neurophysiological Characterization of Thalamic Nuclei in Epileptic Anaesthetized Patients" Brain Sciences 9, no. 11: 312. https://doi.org/10.3390/brainsci9110312