Semi-Automatic Signature-Based Segmentation Method for Quantification of Neuromelanin in Substantia Nigra
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. MR Parameters and Study Protocol
2.3. Segmentation of Brain and Brainstem
2.4. Segmentation of Substantia Nigra, Surface and Volumetric Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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PD | HC | |
---|---|---|
Number | 20 | 12 |
Age | 67.1 ± 4.8 | 64.0 ± 4.8 |
Duration of PD | 3.7 ± 2.8 | / |
HY | 2.1 ± 0.2 | / |
MMSE | 29.8 ± 0.5 | 29.2 ± 1.1 |
PD | HC | Group Comparison | |
---|---|---|---|
Surface (mm2) | 37.7 ± 8.0 | 56.9 ± 6.6 | p = 0.0001 |
Volume (mm3) | 235.1 ± 45.4 | 382.9 ± 100.5 | p = 0.002 |
SInorm | 1.27 ± 0.04 | 1.28 ± 0.03 | p = 0.861 |
PD | HC | Group Comparison | |
---|---|---|---|
MV (mm3) | 6244.8 ± 650 | 6391.1 ± 864.3 | p = 0.877 |
Surface/MV | 6.1 ± 1.4 | 9.1 ± 1.7 | p = 0.001 |
Volume/MV | 3.8 ± 0.7 | 6.0 ± 1.5 | p = 0.0004 |
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Zupan, G.; Šuput, D.; Pirtošek, Z.; Vovk, A. Semi-Automatic Signature-Based Segmentation Method for Quantification of Neuromelanin in Substantia Nigra. Brain Sci. 2019, 9, 335. https://doi.org/10.3390/brainsci9120335
Zupan G, Šuput D, Pirtošek Z, Vovk A. Semi-Automatic Signature-Based Segmentation Method for Quantification of Neuromelanin in Substantia Nigra. Brain Sciences. 2019; 9(12):335. https://doi.org/10.3390/brainsci9120335
Chicago/Turabian StyleZupan, Gašper, Dušan Šuput, Zvezdan Pirtošek, and Andrej Vovk. 2019. "Semi-Automatic Signature-Based Segmentation Method for Quantification of Neuromelanin in Substantia Nigra" Brain Sciences 9, no. 12: 335. https://doi.org/10.3390/brainsci9120335