Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Ethics Statement
2.3. Experimental Design and Sample Collection
2.4. Determination of Serum Hepatic Function Biomarkers
2.5. Determination of Liver Antioxidant Enzyme Activities and Malondialdehyde
2.6. Histopathological Studies
2.7. Statistical Analysis
3. Results
3.1. Effect of CURC on Liver Biochemical Analyses in Rats
3.2. Activity of Antioxidant Enzymes SOD, CAT, and GPx
3.3. Lipid Peroxidation
3.4. Histopathological Examination
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Groups | ALT (U/L) | AST (U/L) | ALP (U/L) | TOTAL PROTEIN (g/dL) |
---|---|---|---|---|
CONTROL | 45.33 ± 6.4 | 118.82 ± 1.45 | 25.60 ± 5.8 | 81.55 ± 3.49 |
CURC | 40.11 ± 5.3 | 100.50 ± 6.2 | 21.50 ± 5.6 | 84.47 ± 1.35 |
OTA | 102.21 ± 5.8 **** | 188.91 ± 4.6 **** | 88.32 ± 4.9 **** | 53.25 ± 2.55 * |
OTA + CURC | 78.20 ± 4.7 #### | 157.72 ± 6.1 ### | 57.31 ± 5.2 ### | 77.14 ± 2.36 # |
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Damiano, S.; Longobardi, C.; Andretta, E.; Prisco, F.; Piegari, G.; Squillacioti, C.; Montagnaro, S.; Pagnini, F.; Badino, P.; Florio, S.; et al. Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats. Antioxidants 2021, 10, 125. https://doi.org/10.3390/antiox10010125
Damiano S, Longobardi C, Andretta E, Prisco F, Piegari G, Squillacioti C, Montagnaro S, Pagnini F, Badino P, Florio S, et al. Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats. Antioxidants. 2021; 10(1):125. https://doi.org/10.3390/antiox10010125
Chicago/Turabian StyleDamiano, Sara, Consiglia Longobardi, Emanuela Andretta, Francesco Prisco, Giuseppe Piegari, Caterina Squillacioti, Serena Montagnaro, Francesco Pagnini, Paola Badino, Salvatore Florio, and et al. 2021. "Antioxidative Effects of Curcumin on the Hepatotoxicity Induced by Ochratoxin A in Rats" Antioxidants 10, no. 1: 125. https://doi.org/10.3390/antiox10010125