Plant-Derived Polyphenols as Nrf2 Activators to Counteract Oxidative Stress and Intestinal Toxicity Induced by Deoxynivalenol in Swine: An Emerging Research Direction
Abstract
:1. Introduction
2. The Physicochemical Characteristics of DON
3. DON-Induced Enterotoxicity in Swine
4. Plant-Derived Polyphenol Application to Counteract Oxidative Stress and Intestinal Toxicity Induced by Deoxynivalenol in Swine
4.1. Resveratrol
4.2. Oxyresveratrol
4.3. Baicalin
4.4. Ferulic Acid
4.5. Quercetin
4.6. Dihydromyricetin
4.7. Chlorogenic Acid
4.8. Astilbin
4.9. Rosmarinic Acid
5. Potential Mechanism of Action: Activation of Nrf2 by the Polyphenols
6. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Polyphenols | In Vivo/In Vitro Model | Polyphenol Doses and Duration | DON Doses and Duration | Main Findings (Polyphenol + DON Treatment vs. DON Treatment) | References |
---|---|---|---|---|---|
Resveratrol | Piglets | 300 mg/kg, 21 days (Cotreatment with DON) | 2.65 mg/kg, 21 days |
| [21] |
| |||||
| |||||
Resveratrol | Piglets | 300 mg/kg, 28 days (Cotreatment with DON) | 3.8 mg/kg, 28 days |
| [31] |
| |||||
| |||||
| |||||
| |||||
Resveratrol | Piglets | 300 mg/kg, 28 days (Cotreatment with DON) | 3.8 mg/kg, 28 days |
| [34] |
| |||||
Resveratrol | IPEC-J2 cells | 15 µM, 24 h (pretreatment) | 0.5 μg/mL, 24 h |
| [34] |
| |||||
Resveratrol | IPEC-J2 cells | 15 µM, 24 h (pretreatment) | 0.5 μg/mL, 24 h |
| [10] |
| |||||
| |||||
Resveratrol | IPEC-J2 cells | 50 µM, 12 h (1 h pretreatment and 11 h cotreatment with DON) | 4 μM, 11 h |
| [32] |
| |||||
| |||||
| |||||
Oxyresveratrol | IPEC-J2 cells | 25 µM, 12 (1 h pretreatment and 11 h cotreatment with DON) | 4 μM, 12 h |
| [35] |
| |||||
Baicalin | Piglets | 0.1%, 14 days (Cotreatment with DON) | 4 mg/kg, 14 days |
| [33] |
| |||||
| |||||
| |||||
| |||||
| |||||
| |||||
Baicalin-copper | Piglets | 5 g/kg, 14 days (Cotreatment with DON) | 4 mg/kg, 14 days |
| [36] |
Ferulic acid | IPEC-J2 cells | 60 µM, 12 h (pretreatment) | 40 µM, 12 h |
| [37] |
| |||||
| |||||
| |||||
| |||||
| |||||
| |||||
Quercetin | IPEC-J2 cells | 20 μM, 24 h (pretreatment) | 1 μM, 1 h |
| [38] |
| |||||
Dihydromyricetin | IPEC-J2 cells | 40 μM, 24 h (cotreatment with DON) | 250 ng/mL, 24 h |
| [29] |
| |||||
| |||||
| |||||
Chlorogenic acid | IPEC-J2 cells | 40 µg/mL, 1 h (Pretreatment) | 0.5 µg/mL, 6 h |
| [39] |
| |||||
| |||||
| |||||
| |||||
Astilbin | IPEC-J2 cells | 20 μg/mL, 6 h (cotreatment with DON) | 0.5 μg/mL, 6 h |
| [28] |
| |||||
| |||||
| |||||
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Rosmarinic acid | IPEC-J2 cells | 50 μM, 24 h (pretreatment) | 1 μM DON and 5 nmol/L T-2, 48 and 72 h |
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Chen, J.; Huang, Z.; Cao, X.; Chen, X.; Zou, T.; You, J. Plant-Derived Polyphenols as Nrf2 Activators to Counteract Oxidative Stress and Intestinal Toxicity Induced by Deoxynivalenol in Swine: An Emerging Research Direction. Antioxidants 2022, 11, 2379. https://doi.org/10.3390/antiox11122379
Chen J, Huang Z, Cao X, Chen X, Zou T, You J. Plant-Derived Polyphenols as Nrf2 Activators to Counteract Oxidative Stress and Intestinal Toxicity Induced by Deoxynivalenol in Swine: An Emerging Research Direction. Antioxidants. 2022; 11(12):2379. https://doi.org/10.3390/antiox11122379
Chicago/Turabian StyleChen, Jun, Zhouyin Huang, Xuehai Cao, Xingping Chen, Tiande Zou, and Jinming You. 2022. "Plant-Derived Polyphenols as Nrf2 Activators to Counteract Oxidative Stress and Intestinal Toxicity Induced by Deoxynivalenol in Swine: An Emerging Research Direction" Antioxidants 11, no. 12: 2379. https://doi.org/10.3390/antiox11122379
APA StyleChen, J., Huang, Z., Cao, X., Chen, X., Zou, T., & You, J. (2022). Plant-Derived Polyphenols as Nrf2 Activators to Counteract Oxidative Stress and Intestinal Toxicity Induced by Deoxynivalenol in Swine: An Emerging Research Direction. Antioxidants, 11(12), 2379. https://doi.org/10.3390/antiox11122379