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Antioxidants
Volume 11
Issue 7
10.3390/antiox11071397
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Review

The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis

by
Tatsuya Ogawa
1,* and
Yosuke Ishitsuka
1,2
1
Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan
2
Department of Dermatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan
*
Author to whom correspondence should be addressed.
Antioxidants 2022, 11(7), 1397; https://doi.org/10.3390/antiox11071397
Submission received: 17 June 2022 / Revised: 16 July 2022 / Accepted: 18 July 2022 / Published: 19 July 2022
(This article belongs to the Special Issue Role of Oxidative Stress in the Dermatological Diseases)
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Abstract

The Kelch-like erythroid cell-derived protein with cap‘n’collar homology-associated protein 1 (KEAP1)-nuclear factor erythroid-2-related factor 2 (NRF2) system, a thiol-based sensor-effector apparatus, exerts antioxidative and anti-inflammatory effects and maintains skin homeostasis. Thus, NRF2 activation appears to be a promising treatment option for various skin diseases. However, NRF2-mediated defense responses may deteriorate skin inflammation in a context-dependent manner. Atopic dermatitis (AD) and psoriasis are two common chronic inflammatory skin diseases caused by a defective skin barrier, dysregulated immune responses, genetic predispositions, and environmental factors. This review focuses on the role of the KEAP1-NRF2 system in the pathophysiology of AD and psoriasis and the therapeutic approaches that utilize this system.
Keywords: antioxidant; atopic dermatitis; dimethyl fumarate; eczema; KEAP1-NRF2 system; mouse model; psoriasis; redox antioxidant; atopic dermatitis; dimethyl fumarate; eczema; KEAP1-NRF2 system; mouse model; psoriasis; redox

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MDPI and ACS Style

Ogawa, T.; Ishitsuka, Y. The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis. Antioxidants 2022, 11, 1397. https://doi.org/10.3390/antiox11071397

AMA Style

Ogawa T, Ishitsuka Y. The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis. Antioxidants. 2022; 11(7):1397. https://doi.org/10.3390/antiox11071397

Chicago/Turabian Style

Ogawa, Tatsuya, and Yosuke Ishitsuka. 2022. "The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis" Antioxidants 11, no. 7: 1397. https://doi.org/10.3390/antiox11071397

APA Style

Ogawa, T., & Ishitsuka, Y. (2022). The Role of KEAP1-NRF2 System in Atopic Dermatitis and Psoriasis. Antioxidants, 11(7), 1397. https://doi.org/10.3390/antiox11071397

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