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Review

Melatonin’s Impact on Wound Healing

1
Department of Bio-Health Convergence, Kangwon National University, Chuncheon 24341, Republic of Korea
2
Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea
3
Department of Convergence Biomedical Science, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Busan 47392, Republic of Korea
*
Authors to whom correspondence should be addressed.
Antioxidants 2024, 13(10), 1197; https://doi.org/10.3390/antiox13101197
Submission received: 28 August 2024 / Revised: 30 September 2024 / Accepted: 1 October 2024 / Published: 2 October 2024

Abstract

Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various tissues, such as the skin and intestines. Melatonin’s effects in target tissues can be mediated through receptor-dependent mechanisms. Additionally, melatonin exerts various actions via receptor-independent pathways. In biological systems, melatonin and its endogenous metabolites often produce similar effects. While injuries are common in daily life, promoting optimal wound healing is essential for patient well-being and healthcare outcomes. Beyond regulating circadian rhythms as a neuroendocrine hormone, melatonin may enhance wound healing through (1) potent antioxidant properties, (2) anti-inflammatory actions, (3) infection control, (4) regulation of vascular reactivity and angiogenesis, (5) analgesic (pain-relieving) effects, and (6) anti-pruritic (anti-itch) effects. This review aims to provide a comprehensive overview of scientific studies that demonstrate melatonin’s potential roles in supporting effective wound healing.
Keywords: antioxidant; inflammation; injury; melatonin; oxidative stress; pineal gland; wound healing antioxidant; inflammation; injury; melatonin; oxidative stress; pineal gland; wound healing

Share and Cite

MDPI and ACS Style

Sohn, E.-H.; Kim, S.-N.; Lee, S.-R. Melatonin’s Impact on Wound Healing. Antioxidants 2024, 13, 1197. https://doi.org/10.3390/antiox13101197

AMA Style

Sohn E-H, Kim S-N, Lee S-R. Melatonin’s Impact on Wound Healing. Antioxidants. 2024; 13(10):1197. https://doi.org/10.3390/antiox13101197

Chicago/Turabian Style

Sohn, Eun-Hwa, Su-Nam Kim, and Sung-Ryul Lee. 2024. "Melatonin’s Impact on Wound Healing" Antioxidants 13, no. 10: 1197. https://doi.org/10.3390/antiox13101197

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