Free-Radical Scavenging and Antioxidant Properties of Melatonin, 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1527

Special Issue Editors


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Guest Editor
Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, 37007 Salamanca, Spain
Interests: oxidative stress; autophagy; lipophagy; metabolism; neuroscience; liver; metabolic diseases
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Institute of Neurosciences of Castilla and León, University of Salamanca, 37007 Salamanca, Spain
2. Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain
Interests: zebrafish; congenital heart diseases; development; neuroscience
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Melatonin, primarily recognized for its involvement in regulating seasonal reproductive phenomena, has emerged as a fascinating molecule with diverse biological effects, including its well-established antioxidant properties. 

Melatonin can maintain mitochondrial homeostasis, enhancing the activity of mitochondrial respiratory complexes I and IV, and promoting increased ATP production. These mechanisms contribute to protection against oxidative stress and support overall cellular health. Additionally, melatonin has demonstrated apoptotic effects in tumor cells, suggesting its potential application as a cancer treatment or adjunct therapy. 

This Special Issue, "Free-Radical Scavenging and Antioxidant Properties of Melatonin, 2nd Edition", is a continuation of the fruitful first volume. It will continue to collect original research articles, reviews, and short communications which explore the antioxidant properties of melatonin and its metabolites in normal physiology and in different pathologies using different models (yeast, plants, mice, and so on) and in clinical settings.

Dr. Marina Garcia-Macia
Dr. Adrián Santos-Ledo
Guest Editors

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Published Papers (1 paper)

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Research

19 pages, 8385 KiB  
Article
Mitochondria of Porcine Oocytes Synthesize Melatonin, Which Improves Their In Vitro Maturation and Embryonic Development
by Tianqi Zhu, Laiqing Yan, Shoulong Deng, Wenkui Ma, Fan Xia, Likai Wang, Xiao Ma, Guangdong Li, Zixia Shen, Yiwei Wang, Yao Fu, Pengyun Ji, Bingyuan Wang, Lu Zhang and Guoshi Liu
Antioxidants 2024, 13(7), 814; https://doi.org/10.3390/antiox13070814 - 7 Jul 2024
Viewed by 1060
Abstract
The in vitro maturation efficiency of porcine oocytes is relatively low, and this limits the production of in vitro porcine embryos. Since melatonin is involved in mammalian reproductive physiology, in this study, we have explored whether endogenously produced melatonin can help in porcine [...] Read more.
The in vitro maturation efficiency of porcine oocytes is relatively low, and this limits the production of in vitro porcine embryos. Since melatonin is involved in mammalian reproductive physiology, in this study, we have explored whether endogenously produced melatonin can help in porcine oocyte in vitro maturation. We have found, for the first time in the literature, that mitochondria are the major sites for melatonin biosynthesis in porcine oocytes. This mitochondrially originated melatonin reduces ROS production and increases the activity of the mitochondrial respiratory electron transport chain, mitochondrial biogenesis, mitochondrial membrane potential, and ATP production. Therefore, melatonin improves the quality of oocytes and their in vitro maturation. In contrast, the reduced melatonin level caused by siRNA to knockdown AANAT (siAANAT) is associated with the abnormal distribution of mitochondria, decreasing the ATP level of porcine oocytes and inhibiting their in vitro maturation. These abnormalities can be rescued by melatonin supplementation. In addition, we found that siAANAT switches the mitochondrial oxidative phosphorylation to glycolysis, a Warburg effect. This metabolic alteration can also be corrected by melatonin supplementation. All these activities of melatonin appear to be mediated by its membrane receptors since the non-selective melatonin receptor antagonist Luzindole can blunt the effects of melatonin. Taken together, the mitochondria of porcine oocytes can synthesize melatonin and improve the quality of oocyte maturation. These results provide an insight from a novel aspect to study oocyte maturation under in vitro conditions. Full article
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