Next Article in Journal
uL3 Regulates Redox Metabolism and Ferroptosis Sensitivity of p53-Deleted Colorectal Cancer Cells
Previous Article in Journal
Mass Yields, Antioxidant and Anti-DU145 Prostate Cancer Cell Proliferation Properties of ProSoy Soymilk as Affected by Extraction Methods and Cooking
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antioxidants
Volume 13
Issue 7
10.3390/antiox13070756
antioxidants-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses

by
Milica Manojlović-Stojanoski
1,*,
Slavica Borković-Mitić
1,
Nataša Nestorović
1,
Nataša Ristić
1,
Radomir Stefanović
2,3,
Magdalena Stevanović
4,
Nenad Filipović
4,
Aleksandar Stojsavljević
5 and
Slađan Pavlović
1
1
Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11108 Belgrade, Serbia
2
Department of Pathology and Medical Citology, University Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia
3
Faculty of Medicine, University of Belgrade, dr Koste Todorovića 26, 11000 Belgrde, Serbia
4
Group for Biomedical Engineering and Nanobiotechnology, Institute of Technical Sciences of the Serbian Academy of Sciences and Arts (SASA), Kneza Mihaila 35/IV, 11000 Belgrade, Serbia
5
Innovative Centre, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Antioxidants 2024, 13(7), 756; https://doi.org/10.3390/antiox13070756
Submission received: 23 May 2024 / Revised: 13 June 2024 / Accepted: 18 June 2024 / Published: 21 June 2024
Browse Figures
Review Reports Versions Notes

Abstract

To compare the effects of organic selenium nanoparticles (SeNPs, Se0) and inorganic sodium selenite (NaSe, Na2SeO3, Se4+) on the antioxidant response in maternal and fetal rat liver, pregnant females were treated with two forms of selenium (Se) at equivalent doses during gestation (0.5 mg SeNPs or 0.5 mg NaSe/kg body weight/day). Structural parameters of the liver of gravid females and their fetuses were examined in a sex-specific manner. The oxidative stress parameters superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione S-transferase (GST), total glutathione (GSH) and sulfhydryl groups (SH) were established. In addition, the Se concentration was determined in the blood, liver, urine and feces of the gravid females and in the liver of the fetuses. The structure of the liver of gravid females remained histologically the same after supplementation with both forms of Se, while the oxidative stress in the liver was significantly lower after the use of SeNPs compared to NaSe. Immaturity of fetal antioxidant defenses and sex specificity were demonstrated. This study provides a detailed insight into the differences in the bioavailability of the nano form of Se compared to sodium selenite in the livers of pregnant females and fetuses.
Keywords: antioxidant response; selenium nanoparticles; sodium selenite; pregnancy; fetuses; liver; histology; oxidative stress parameters; sex differences antioxidant response; selenium nanoparticles; sodium selenite; pregnancy; fetuses; liver; histology; oxidative stress parameters; sex differences
Graphical Abstract

Share and Cite

MDPI and ACS Style

Manojlović-Stojanoski, M.; Borković-Mitić, S.; Nestorović, N.; Ristić, N.; Stefanović, R.; Stevanović, M.; Filipović, N.; Stojsavljević, A.; Pavlović, S. Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses. Antioxidants 2024, 13, 756. https://doi.org/10.3390/antiox13070756

AMA Style

Manojlović-Stojanoski M, Borković-Mitić S, Nestorović N, Ristić N, Stefanović R, Stevanović M, Filipović N, Stojsavljević A, Pavlović S. Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses. Antioxidants. 2024; 13(7):756. https://doi.org/10.3390/antiox13070756

Chicago/Turabian Style

Manojlović-Stojanoski, Milica, Slavica Borković-Mitić, Nataša Nestorović, Nataša Ristić, Radomir Stefanović, Magdalena Stevanović, Nenad Filipović, Aleksandar Stojsavljević, and Slađan Pavlović. 2024. "Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses" Antioxidants 13, no. 7: 756. https://doi.org/10.3390/antiox13070756

APA Style

Manojlović-Stojanoski, M., Borković-Mitić, S., Nestorović, N., Ristić, N., Stefanović, R., Stevanović, M., Filipović, N., Stojsavljević, A., & Pavlović, S. (2024). Antioxidant Response of Maternal and Fetal Rat Liver to Selenium Nanoparticle Supplementation Compared to Sodium Selenite: Sex Differences between Fetuses. Antioxidants, 13(7), 756. https://doi.org/10.3390/antiox13070756

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop