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Open AccessReview
Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions
by
Héctor Vázquez-Lorente
Héctor Vázquez-Lorente 1,2,†
,
Lourdes Herrera-Quintana
Lourdes Herrera-Quintana 1,2,†
,
Laura Jiménez-Sánchez
Laura Jiménez-Sánchez 1,2,3,
Beatriz Fernández-Perea
Beatriz Fernández-Perea 4 and
Julio Plaza-Diaz
Julio Plaza-Diaz 3,5,6,*
1
Department of Physiology, Schools of Pharmacy and Medicine, University of Granada, 18071 Granada, Spain
2
Biomedical Research Center, Health Sciences Technology Park, University of Granada, 18016 Granada, Spain
3
Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain
4
Immunology and Clinical Analysis Service, Virgen de las Nieves University Hospital, 18014 Granada, Spain
5
Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071 Granada, Spain
6
Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2024, 13(8), 996; https://doi.org/10.3390/antiox13080996 (registering DOI)
Submission received: 31 July 2024
/
Revised: 11 August 2024
/
Accepted: 17 August 2024
/
Published: 17 August 2024
Abstract
Evidence is increasing that vitamin D and CYP11A1-derived vitamin D, tachysterol, and lumisterol metabolites play a significant antioxidant role beyond its classical functions in bone health and calcium metabolism. Several recent studies have linked these elements to reduced oxidative stress as well as improved immune, cardiovascular, and neurological functions as a result of chronic kidney disease and cancer. Additionally, supplementation with this vitamin has been shown to be one of the most cost-effective micronutrient interventions worldwide, highlighting its potential as a therapeutic approach. The underlying mechanisms and implications of this antioxidant function of vitamin D or CYP11A1-derived vitamin D, tachysterol, and lumisterol metabolites are not well understood. This comprehensive and narrative review is aimed at summarizing the current evidence regarding the molecular mechanisms implicated in this antioxidant function of vitamin D, as well as to provide a general overview and to identify key research areas for the future, offering an extensive perspective that can guide both researchers and clinicians in the management of diseases associated with oxidative stress and/or insufficient vitamin D status.
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MDPI and ACS Style
Vázquez-Lorente, H.; Herrera-Quintana, L.; Jiménez-Sánchez, L.; Fernández-Perea, B.; Plaza-Diaz, J.
Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions. Antioxidants 2024, 13, 996.
https://doi.org/10.3390/antiox13080996
AMA Style
Vázquez-Lorente H, Herrera-Quintana L, Jiménez-Sánchez L, Fernández-Perea B, Plaza-Diaz J.
Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions. Antioxidants. 2024; 13(8):996.
https://doi.org/10.3390/antiox13080996
Chicago/Turabian Style
Vázquez-Lorente, Héctor, Lourdes Herrera-Quintana, Laura Jiménez-Sánchez, Beatriz Fernández-Perea, and Julio Plaza-Diaz.
2024. "Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions" Antioxidants 13, no. 8: 996.
https://doi.org/10.3390/antiox13080996
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