Long-Term Dynamic Humoral Response to SARS-CoV-2 mRNA Vaccines in Patients on Peritoneal Dialysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Design
2.2. Population
2.3. Objectives and Outcomes
2.4. Variables
2.5. Statistics
3. Results
3.1. Baseline Characteristics
3.2. Humoral Response after the Initial Vaccination Schedule
3.3. Humoral Response after the Third Dose at 6 Months
3.4. Humoral Response after the Fourth Dose at 6 Months
3.5. Factors Associated with Stronger Humoral Response at 12 Months
3.6. Breakthrough Infections
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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B (95%CI) | p | |
---|---|---|
Age (years) | 44 (−52, 141) | 0.913 |
Gender (male) | 1726 (−519, 3972) | 0.129 |
mRNA-based vaccine (mRNA-1273) | −914 (−3054, 1225) | 0.394 |
Fourth dose (yes) | 2086 (−386, 4560) | 0.096 |
Anti-Spike antibody titers at 6 months (per UI/mL) | 0.530 (0.274, 0.786) | <0.001 |
Patient | Timing of COVID-19 | Initial SARS-CoV-2 Vaccine | Third SARS-CoV-2 Vaccine Dose | Last Anti-Spike Titers Prior to COVID-19 (mUI/L) | Infection Severity | Anti-Spike Titers Post-COVID-19 (mUI/L) |
---|---|---|---|---|---|---|
1 | Before 3rd dose | BNT162b2 | -- | 1065 | Mild symptoms without admission | 6599 |
2 | Before 4th dose | mRNA-1273 | mRNA-1273 | 3135 | Mild symptoms without admission | 10,000 |
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Quiroga, B.; Soler, M.J.; Ortiz, A.; Gansevoort, R.T.; Leyva, A.; Rojas, J.; de Sequera, P., on behalf of SENCOVAC Collaborative Network. Long-Term Dynamic Humoral Response to SARS-CoV-2 mRNA Vaccines in Patients on Peritoneal Dialysis. Vaccines 2022, 10, 1738. https://doi.org/10.3390/vaccines10101738
Quiroga B, Soler MJ, Ortiz A, Gansevoort RT, Leyva A, Rojas J, de Sequera P on behalf of SENCOVAC Collaborative Network. Long-Term Dynamic Humoral Response to SARS-CoV-2 mRNA Vaccines in Patients on Peritoneal Dialysis. Vaccines. 2022; 10(10):1738. https://doi.org/10.3390/vaccines10101738
Chicago/Turabian StyleQuiroga, Borja, María José Soler, Alberto Ortiz, Ron T. Gansevoort, Alba Leyva, José Rojas, and Patricia de Sequera on behalf of SENCOVAC Collaborative Network. 2022. "Long-Term Dynamic Humoral Response to SARS-CoV-2 mRNA Vaccines in Patients on Peritoneal Dialysis" Vaccines 10, no. 10: 1738. https://doi.org/10.3390/vaccines10101738