Comparative Immunogenicity of a High-Dose Hepatitis B Virus (HBV) Vaccine with Rapid Immunization vs. Standard Schedule in HBV Vaccine—Naïve Adults Aged 25–55 in China
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Population
2.3. Vaccines
2.4. Serological Tests
2.5. Statistical Analyses
3. Results
3.1. Demographics Analysis
3.2. Immunogenicity
3.3. Immune Response of Adults in Different Age Groups
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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20 µg | 60 µg | p Value | |
---|---|---|---|
Subjects, no | 289 | 294 | |
Age, Mean (SD) | 40.3 (7.1) | 39.5 (7.7) | 0.1934 |
25~<30 years, N (%) | 26 (9.0) | 32 (10.9) | 0.0116 |
30~<35 years, N (%) | 36 (12.5) | 52 (17.7) | |
35~<40 years, N (%) | 47 (16.3) | 52 (17.7) | |
40~<45 years, N (%) | 109 (37.7) | 74 (25.2) | |
45~<50 years, N (%) | 40 (13.8) | 59 (20.1) | |
50~55 years, N (%) | 31 (10.7) | 25 (8.5) | |
Sex, N (%) | |||
Male | 126 (43.6) | 145 (49.3) | 0.1661 |
Female | 163 (56.4) | 149 (50.7) | |
BMI, Mean (SD) | 23.8 (3.1) | 23.9 (3.0) | 0.4939 |
History of smoke, N (%) | 76 (26.3) | 97 (33.0) | 0.0769 |
History of drink, N (%) | 80 (27.7) | 81 (27.6) | 0.9719 |
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Qiu, Q.; Wang, H.; Liu, X.; Pang, X.; Zhang, W. Comparative Immunogenicity of a High-Dose Hepatitis B Virus (HBV) Vaccine with Rapid Immunization vs. Standard Schedule in HBV Vaccine—Naïve Adults Aged 25–55 in China. Vaccines 2024, 12, 923. https://doi.org/10.3390/vaccines12080923
Qiu Q, Wang H, Liu X, Pang X, Zhang W. Comparative Immunogenicity of a High-Dose Hepatitis B Virus (HBV) Vaccine with Rapid Immunization vs. Standard Schedule in HBV Vaccine—Naïve Adults Aged 25–55 in China. Vaccines. 2024; 12(8):923. https://doi.org/10.3390/vaccines12080923
Chicago/Turabian StyleQiu, Qian, Huai Wang, Xiuying Liu, Xinghuo Pang, and Wei Zhang. 2024. "Comparative Immunogenicity of a High-Dose Hepatitis B Virus (HBV) Vaccine with Rapid Immunization vs. Standard Schedule in HBV Vaccine—Naïve Adults Aged 25–55 in China" Vaccines 12, no. 8: 923. https://doi.org/10.3390/vaccines12080923