Maternal Immunization with Adjuvanted Recombinant Receptor-Binding Domain Protein Provides Immune Protection against SARS-CoV-2 in Infant Monkeys
Abstract
:1. Introduction
2. Methods
2.1. Subjects
2.2. Blood Collection
2.3. Immunization
2.4. Antibody Response
2.5. ACE2 Neutralization Assay
2.6. Comparison with Placental Transfer of Maternal Antibody to Tetanus Toxoid (TT)
2.7. Statistical Analyses
3. Results
3.1. Pregnancy Outcomes
3.2. Antibody Response to Immunization
3.3. Placental Transfer of Maternal IgG to RBD-Fc
3.4. ACE2 Neutralization
3.5. Placental Transfer of IgG1 against Tetanus Toxoid (TT)
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Coe, C.L.; Nimityongskul, F.; Lubach, G.R.; Luke, K.; Rancour, D.; Schomburg, F.M. Maternal Immunization with Adjuvanted Recombinant Receptor-Binding Domain Protein Provides Immune Protection against SARS-CoV-2 in Infant Monkeys. Vaccines 2024, 12, 929. https://doi.org/10.3390/vaccines12080929
Coe CL, Nimityongskul F, Lubach GR, Luke K, Rancour D, Schomburg FM. Maternal Immunization with Adjuvanted Recombinant Receptor-Binding Domain Protein Provides Immune Protection against SARS-CoV-2 in Infant Monkeys. Vaccines. 2024; 12(8):929. https://doi.org/10.3390/vaccines12080929
Chicago/Turabian StyleCoe, Christopher L., Francesca Nimityongskul, Gabriele R. Lubach, Kimberly Luke, David Rancour, and Fritz M. Schomburg. 2024. "Maternal Immunization with Adjuvanted Recombinant Receptor-Binding Domain Protein Provides Immune Protection against SARS-CoV-2 in Infant Monkeys" Vaccines 12, no. 8: 929. https://doi.org/10.3390/vaccines12080929